2011 Fiscal Year Final Research Report
Identification of molecular target for malignant lymphoma treatment through understanding of clinicopathological genes
| Project/Area Number |
22790909
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Mie University |
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Principal Investigator |
MIYAZAKI Kana 三重大学, 大学院・医学系研究科, 助教 (60571627)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 悪性リンパ腫 / 網羅的遺伝子解析 / びまん性大細胞型B細胞リンパ腫 / 中枢神経系 |
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| Research Abstract |
CD5+ DLBCL shows a poor prognosis and high incidence of central nervous system relapse. By gene expression profiling, we confirmed that most of CD5+ DLBCLs are classified as activated B cell-like DLBCL. A classifier based on gene expression at supervised analysis also correctly identified CD5 expression. The top classifier gene supervised by CD5 expression was SH3BP5. A lot of neurological component-and function-related genes were contained in the CD5 DLBCL signature genes. Immunohistochemical analysis confirmed that SH3BP5 expression was detected on the tumor cell.
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Research Products
(14 results)
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[Journal Article] CD5-positive diffuse large B-cell lymphoma : a retrospective study in 337 patients treated by chemotherapy with or without rituximab2011
Author(s)
Miyazaki K, Yamaguchi M, Suzuki R, Kobayashi Y, Maeshima AM, Niitsu N, Ennishi D, Tamaru JI, Ishizawa K, Kashimura M, Kagami Y, Sunami K, Yamane H, Nishikori M, Kosugi H, Yujiri T, Hyo R, Katayama N, Kinoshita T, Nakamura S
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Journal Title
Ann Oncol
Volume: 22
Pages: 1601-1607
Peer Reviewed
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[Presentation] Cytogenetic features of CD5-positive diffuse large B-cell lymphoma : updated results from a multicenter, retrospective study with 77 patients2011
Author(s)
K Miyazaki, M Yamaguchi, J Tamaru, N Niitsu, T Yujiri, K Sunami, N Nakamura, T Kinoshita, M Kato, R Suzuki, S Nakamura, N Katayama, I Miura
Organizer
11th International Conference on Malignant Lymphoma
Place of Presentation
Lugano, Switzerland
Year and Date
2011-06-04
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