2011 Fiscal Year Final Research Report
Control of leukemic stem cells by the bone marrow microenvironments
| Project/Area Number |
22790910
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 血液腫瘍学 / 白血病幹細胞ニッチ / 白血病 / ケモカイン / CXCR4 |
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| Research Abstract |
In the bone marrow, leukemic stem cells(LSCs), the most important target for leukemic therapy, are maintained by special microenvironments, termed niches. The nature and function of these niches, however, remains unclear. Here we showed that using mouse chronic myeloid leukemia model,(1) the microenvironments in bone marrow were altered with progression of leukemia,(2) LSCs grew up in altered microenvironments,(3) B lymphopoiesis in the bone marrow was impaired along with elevated inflammatory cytokines(e. g. IL6), and(4) identified candidates of cell components of LSC niches. These studies offer innovative strategies for leukemia therapy targeting the LSCs niches.
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