2011 Fiscal Year Final Research Report
Regulation of allergic inflammation by liver X receptor
| Project/Area Number |
22790946
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | マスト細胞 / 炎症 / 核内受容体 / アレルギー |
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| Research Abstract |
In the present study, we examined the role of liver X receptor(LXR)α and β, which are representative nuclear receptors, on regulation of cytokine production by mast cells. We demonstrated for the first time that activation of LXRα but not LXRβ reppresses IL-1α and IL-1β expression in mast cells. These data suggest that regulation of LXRβ activation may be a useful aproach to reppress mast cell function as inflammatory cells.
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