2011 Fiscal Year Final Research Report
Mucosal-associated invariant T cells in the pathogenesis of arthritis.
| Project/Area Number |
22790950
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
CHIBA Asako 独立行政法人国立精神・神経医療研究センター, 神経研究所免疫研究部, 非常勤研究員 (40532726)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 関節炎 / 自然リンパ球 / マウスモデル |
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| Research Abstract |
We revealed that Mucosal-Associated Invariant T cells(MAIT cells) promote inflammation and exacerbate arthritis by using two mouse models of arthritis. We also demonstrated that MAIT cells became activated upon stimulation with IL-1βor IL-23 even in the absence of T cell receptor stimuli. These results indicate that MAIT cells may exert different functions depending on the pathologic condition and contribute to augment disease in arthritis models.
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[Journal Article] Innate recognition of cell wallβ-glucans drives invariant natural killer T cell responses against fungi2011
Author(s)
Cohen NR, Tatituri RV, Rivera A, Watts GF, Kim EY, Chiba A, Fuchs BB, Mylonakis E, Besra GS, Levits SM, Brigl M, Brenner MB
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Journal Title
Cell Host Microbe
Volume: 10
Pages: 437-45
DOI
Peer Reviewed
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