Mechanisms for allergen-induced airway inflammation regulated by non-adoptive immune system.

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790951
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: National Research Institute for Child Health and Development
• Principal Investigator: OBOKI Keisuke 独立行政法人国立成育医療研究センター, 免疫アレルギー研究部, 上級研究員 (80415108)
• Project Period (FY): 2010 – 2011
• Keywords: サイトカイン / 喘息 / IL-33

Research Abstract

Our results suggest that allergen Der f 1 or papain induce airway inflammation solely by its protease activity in the rapid time course.

Research Products

• [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice (2012)
  • Author(s): Morita H, Arae K, Ohno T, Kajiwara N, Oboki, K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae, S
  • Journal Title: Allergol Int Volume: 61(2) Pages: 265-73
  • DOI: DOI:10.2332/allergolint.11-OA-0379
• [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness (2012)
  • Author(s): Sawaguchi M, Oboki, K,(8番目) Nakae, S,(12番目) Kubo M
  • Journal Title: J Immunol Volume: 188(4) Pages: 1809-18
  • DOI: DOI:10.4049/jimmunol.1101746
• [Journal Article] Cimetidine enhances antigen-specific IgE and Th2 cytokine production (2011)
  • Author(s): Arae K, Oboki, K, Ohno T, Hirata M, Nakae, S, Taguchi H, Saito, H, Nakajima T
  • Journal Title: Allergol Int Volume: 60(3) Pages: 339-44
  • DOI: DOI:10.2332/allergolint.10-OA-0255
• [Journal Article] Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation (2011)
  • Author(s): Ohno T, Oboki, K, Morita H, Kajiwara N, Arae K, Tanaka S, Ikeda M, Iikura M, Akiyama T, Inoue J, Matsumoto K, Sudo K, Azuma M, Okumura K, Kamradt T, Saito, H, Nakae, S
  • Journal Title: PLoS One Volume: 6(4) Pages: 18404
  • DOI: DOI:10.1371/journal.pone.0018404.
• [Journal Article] IL-33 and Airway Inflammation (2011)
  • Author(s): Oboki, K, Nakae, S, Matsumoto K, Saito, H
  • Journal Title: Allergy Asthma Immunol Res Volume: 3(2) Pages: 81-8
  • DOI: DOI:10.4168/aair.2011.3.2.81
• [Journal Article] IL-33 is a crucial amplifier of innate rather than acquired immunity (2010)
  • Author(s): Oboki, K, Ohno T, Kajiwara N, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Matsumoto K, Sudo K, Okumura K, Saito, H, Nakae, S
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107(43) Pages: 18581-6
  • DOI: DOI:10.1073/pnas.1003059107
• [Journal Article] Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression (2010)
  • Author(s): Ishii A, Oboki, K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito, H, Nakae, S
  • Journal Title: Allergol Int Volume: 59(4) Pages: 399-408
  • DOI: DOI:10.2332/allergolint.10-OA-0218
• [Journal Article] Amphire-gulin is not essential for induction of contact hypersensitivity (2010)
  • Author(s): Yagami A, Oboki, K,(3番目) Saito, H,(9番目) Nakae, S.(last), et al
  • Journal Title: Allergol Int Volume: 59(3) Pages: 277-84
  • DOI: DOI:10.2332/allergolint.09-OA-0149
• [Journal Article] Amphiregulin is not essential for ovalbumin-induced acute airway inflamma tion in mice (2010)
  • Author(s): Kajiwara N, Oboki, K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito, H, Nakae, S
  • Journal Title: Allergol Int Volume: 59(2) Pages: 207-11
  • DOI: DOI:10.2332/allergolint.09-OA-0144
• [Journal Article] IL-33 and IL-33 receptors in host defense and diseases (2010)
  • Author(s): Oboki, K, Ohno T, Kajiwara N, Saito, H, Nakae, S
  • Journal Title: Allergol Int Volume: 59(2) Pages: 143-60
  • DOI: DOI:10.2332/allergolint.10-RAI-0186
• [Presentation] IL-33 in airway inflammation (2011)
  • Author(s): 大保木啓介
  • Organizer: APAPARI 2010 & 第48回JASPACI(第16回アジア太平洋小児アレルギー呼吸器免疫学会、第48回日本小児アレルギー学会合同大会)
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-29
• [Book] 粘膜における自然免疫:マスト細胞・好酸球・好塩基球、臨床粘膜免疫 (2010)
  • Author(s): 斎藤博久,大保木啓介,中江進,烏山一
  • Total Pages: 79-88
  • Publisher: シナジー、東京