2011 Fiscal Year Final Research Report
Diagnosis of human herpesvirus 6(HHV-6)-associated infection after hematopoietic stem cell transplantation.
| Project/Area Number |
22790954
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kochi University |
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Principal Investigator |
TANIGUCHI Ayuko 高知大学, 教育研究部・医療学系, 助教 (30403885)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ウイルス学 / 感染症学 / ヘルペスウイルス / 染色体 |
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| Research Abstract |
Human herpesvirus 6(HHV-6) infection is recognized as a potentially life-threatening condition affecting hematopoietic stem cell transplantation recipients due to reactivation of the virus from a latent state. For example, HHV-6 can cause acute encephalitis in imunocompromised patients. However, HHV-6 is unique among human herpesviruses because of its ability into chromosomes of the host cells. This entity, termed chromosomally integrated HHV-6(CIHHV-6), has the potential to confound the diagnosis of active HHV-6 infection, since chromosomally integrated HHV-6 DNA sequences are inherited through the germline. Therefore, CIHHV-6 should be distinguishable from acute HHV-6 infection. In all CIHHV-6 cases studied, fluorescence in situ hybridization showed that HHV-6 DNA colocalized with telomeric regions of one allele on chromosomes. It is important to exclude CIHHV-6 before concluding that there is evidence of active HHV-6 infection.
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