2013 Fiscal Year Final Research Report

Analysis of Rickets in the premature baby using a new biomarker, FGF23 and Klotho

Research Project

Project/Area Number	22791028
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Embryonic/Neonatal medicine
Research Institution	Osaka University
Principal Investigator	ARAHORI Hitomi 大阪大学, 医学(系)研究科(研究院), 助教 (40379186)
Project Period (FY)	2010-04-01 – 2013-03-31
Keywords	未熟児くる病 / 新生児 / 骨代謝
Research Abstract	Fibroblast growth factor 23, FGF receptor, and Klotho is known to participate in homeostasis of phosphate metabolism. To determine the baseline levels of these molecule and their correlation, we measured the serum levels of soluble Klotho in fetuses and compare them with those in neonates, mothers, and adults. In cord blood, the level of Klotho was markedly higher than levels in other samples, whereas the fetal level of FGF23 was lower than levels in the other subjects. Immunohistochemistry demonstrated that Klotho was predominantly expressed in syncytiotrophoblasts in normal term placenta.