2011 Fiscal Year Final Research Report
Etiological mechanisms of anxiety disorders induced by fetal alcohol exposure with special reference to fear condition and dynamics state of serotonin.
| Project/Area Number |
22791029
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kagawa University (2011)
The University of Tokushima (2010) |
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Principal Investigator |
OHTA Kenichi 香川大学, 医学部, 助教 (50403720)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 胎生期アルコール曝露 / 不安様行動 / セロトニン / 扁桃体 / 内側前頭前皮質 / マイクロダイアリシス |
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| Research Abstract |
Previous study revealed that abnormalities of brain development induced by fetal alcohol exposure(FAE) were recovered by administration of serotonin 1A receptor agonist during period of brain development. In addition, we found disruption of dynamics state of serotonin under fearful state in mature FAE animals. These results suggest that FAE induces abnormalities of central nerves system via reduction of serotonergic function, mainly meditated by serotonin 1A receptor during period of brain development and prolonged abnormality of 5-HTergic function lead to anxiety-like behavior in mature FAE animals.
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