Analysis of PDA pathogenesis and development of the therapy with novel PDA model mice.

2013 Fiscal Year Final Research Report

• Project/Area Number: 22791041
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Nagoya University (2012-2013); Chubu University (2010-2011)
• Principal Investigator: YAJIMA Ichiro 名古屋大学, 医学(系)研究科(研究院), 助教 (80469022)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Keywords: 先天異常学 / PDA / メラノサイト

Research Abstract

Tyr::Cre; b-catFloxedEx3 mice showed PDA by enhanced activity of b-catenin after birth. In these mice, ectopic melanocytes were localized in the heart and they directly and/or indirectly affect formation of the PDA. Knockout of Mitf, a key molecule for melanocyte development, survival and proliferation, in these model mice inhibited closure of ductus arteriosus by indometacin.

Research Products

• [Journal Article] A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus (2013)
  • Author(s): Yajima I, Colombo S, Puig I, Champeval D, Kumasaka M, Belloir E, Bonaventure J, Mark M, Yamamoto H, Taketo MM, Choquet P, Etchevers HC, Beermann F, Delmas V, Monassier L, Larue L.
  • Journal Title: PLoS One. Volume: 8(1) Pages: e53183
  • Peer Reviewed
• [Journal Article] Functional analysis of GNG2 in human malignant melanoma cells (2012)
  • Author(s): Yajima I, Kumasaka MY, Tamura H, Ohgami N, Kato M
  • Journal Title: J Dermatol Sci. Volume: 68(3) Pages: 172-8
  • Peer Reviewed
• [Journal Article] Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines (2012)
  • Author(s): Yajima I, Kumasaka MY, Naito Y, Yoshikawa T, Takahashi H, Funasaka Y, Suzuki T, Kato M
  • Journal Title: Am J Cancer Res. Volume: 2(3) Pages: 322-9
  • Peer Reviewed
• [Journal Article] A novel hairless mouse model for malignant melanoma (2012)
  • Author(s): Thang ND, Yajima I, Nakagawa K, Tsuzuki T, Kumasaka MY, Ohgami N, Ly TB, Iwamoto T, Watanabe, D, Kato M.
  • Journal Title: J Dermatol Sci. Volume: 65(3) Pages: 207-12
  • Peer Reviewed
• [Journal Article] RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy (2012)
  • Author(s): Yajima I, Kumasaka MY, Thang ND, Goto Y, Takeda K, Yamanoshita O, Iida M, Ohgami N, Tamura H, Kawamoto Y, Kato M
  • Journal Title: Dermatol Res Pract Volume: 2012 Pages: 354191
  • Peer Reviewed
• [Journal Article] Molecular Network Associated with MITF in Skin Melanoma Development and Progression (2011)
  • Author(s): Yajima I, Kumasaka MY, Thang ND, Goto Y, Takeda K, Iida M, Ohgami N, Tamura H, Yamanoshita O, Kawamoto Y, Furukawa K, Kato M
  • Journal Title: J Skin Cancer Volume: 2011 Pages: 730170
  • Peer Reviewed
• [Journal Article] Sunlight exposure-mediated DNA damage in young adults (2011)
  • Author(s): Kato M, Iida M, Goto Y, Kondo T, Yajima I
  • Journal Title: Cancer Epidemiol Biomarkers Prev Volume: 20(8) Pages: 1622-8
  • Peer Reviewed
• [Presentation] メラノーマにおけるGNG2の機能 (2012)
  • Author(s): 矢嶋伊知朗, 熊坂真由子, 大神信孝, 加藤昌志
  • Organizer: 第24回日本色素細胞学会学術大会
  • Place of Presentation: 長浜バイオ大学(長浜市)
  • Year and Date: 20121124-25