2011 Fiscal Year Final Research Report
Proteomic analysis of oxidatively damaged proteins in the sclerotic hippocampus of patients with mesial temporal lobe epilepsy
| Project/Area Number |
22791046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Suzuka University of Medical Science (2011)
Institute for Developmental Research, Aichi Human Service Center (2010) |
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Principal Investigator |
FURUKAWA Ayako 鈴鹿医療科学大学, 薬学部, 助手 (10455537)
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| Project Period (FY) |
2010 – 2011
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| Keywords | てんかん / 酸化ストレス / 興奮毒性 / プロテオミクス / 酸化損傷タンパク質 / 海馬硬化 |
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| Research Abstract |
Free radicals play a critical role in excitotoxin-induced neuronal death. However, it remains unclear which proteins are paticularly vulnerable to excitotoxin-induced oxidative damage in the epileptogenic lesion of patients with hippocampal sclerosis. To identify potential proteins specifically damaged in sclerotic hippocampus of epileptic patients, we performed proteomic analysis of carbonylated proteins in the hippocampus and temporal neocortex prepared from patients with and without hippocampal sclerosis. We found some target proteins that were particularly carbonylated in the sclerotic hippocampus.
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[Journal Article] Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury2011
Author(s)
Furukawa A, Kawamoto Y, Chiba Y, Takei S, Hasegawa-Ishii S, Kawamura N, Yoshikawa K, Hosokawa M, Oikawa S, Kato M, Shimada A
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Journal Title
Neurobiol. Dis
Volume: 43
Pages: 706-714
Peer Reviewed
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[Journal Article] Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1, 2, 4-triazole, a metabolite of carcinogenic amitrole2010
Author(s)
Furukawa A, Oikawa S, Harada K, Sugiyama H, Hiraku Y, Murata M, Shimada A, Kawanishi S
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Journal Title
Mutat Res
Volume: 694
Pages: 7-12
Peer Reviewed
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