2013 Fiscal Year Final Research Report
Analysis of Keap1-Nrf2 system in skin cancers
| Project/Area Number |
22791053
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 癌 / Keap1 / Nrf2 / DNAメチル化 |
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| Research Abstract |
Keap1-Nrf2 system is known as redox homeostasis system, and also involved carcinogenesis. In this study, disruption of Keap1-Nrf2 system in skin cancers was analyzed. Seventy-two skin cancer specimens were collected and analyzed. The mutation of KEAP1 was found in only 1 specimen, and the mutation of NRF2 and LOH in KEAP1 locus were not found. Aberrant methylation of KEAP1 was found in 4 of 72 (6%) specimens; however the methylations were weak to shutoff the expression. In conclusion, disruption of Keap1-Nrf2 system in skin cancers is rare event.
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