2011 Fiscal Year Final Research Report
The role of Th17 and Th22 in the development of atopic dermatitis
| Project/Area Number |
22791068
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kyoto University |
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Principal Investigator |
HONDA Tetsuya 京都大学, 医学研究科, 助教 (40452338)
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| Project Period (FY) |
2010 – 2011
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| Keywords | アトピー性皮膚炎 / Th17細胞 / アレルギー |
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| Research Abstract |
The role of IL-17 in the development of atopic dermatitis(AD) was investigated using mouse AD model. IL-17 deficient mice were applied to the model, and showed reduced clinical symptoms and antigen-specific IgE level in the serum. In the skin IL-17 was produced not only from Th17 cells but also gamma-delta T cells. These results suggest that IL-17 play important role in the establishment of AD.
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Research Products
(3 results)
