2011 Fiscal Year Final Research Report
The role of Th17 and Th22 in the development of atopic dermatitis
| Project/Area Number |
22791068
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
HONDA Tetsuya 京都大学, 医学研究科, 助教 (40452338)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | アトピー性皮膚炎 / Th17細胞 / アレルギー |
|---|
| Research Abstract |
The role of IL-17 in the development of atopic dermatitis(AD) was investigated using mouse AD model. IL-17 deficient mice were applied to the model, and showed reduced clinical symptoms and antigen-specific IgE level in the serum. In the skin IL-17 was produced not only from Th17 cells but also gamma-delta T cells. These results suggest that IL-17 play important role in the establishment of AD.
|
