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2011 Fiscal Year Final Research Report

A role of nuclear import activity on the proliferation of cutaneous diseases

Research Project

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Project/Area Number 22791070
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionOsaka University

Principal Investigator

UMEGAKI Noriko  大阪大学, 医学系・研究科, 助教 (80397629)

Project Period (FY) 2010 – 2011
Keywords核移行シグナル / karyopherinα2 / TAP methods / mass spectrometry / MTSアッセイ
Research Abstract

Detection and analysis of target proteins imported by karyopherin alpha 2(KPNA2) in HaCaT cells using tandem affinity purification method and mass spectrometry to investigate the roles of KPNA2 in the cell growth. Immunohistochemical staining using anti-KPNA2 antibody was performed in the skin diseases including psoriasis and squamous cell carcinomas to demonstrate the relation ship between KPNA2 and keratinocyte proliferation.

  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (2 results)

  • [Journal Article] Pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa2012

    • Author(s)
      Hanafusa T, Tamai K, Umegaki N, Yamaguchi Y, Fukuda S, Nishikawa Y, Yaegashi N, Okuyama R, McGrath JA, Katayama I
    • Journal Title

      Clinical and experimental dermatology

      Volume: 37(1) Pages: 10-4

    • Peer Reviewed
  • [Journal Article] Hereditary angioedema in Japan : Genetic analysis of 13 unrelated cases2012

    • Author(s)
      Yamamoto T, Horiuchi T, Miyahara H, Yoshizawa S, Maehara J, Shono E, Takamura K, Machida H, Tsujioka K, Kaneko T, Uemura N, Suzawa K, , Inagaki N, Umegaki N, Kasamatsu Y, Hara A, Arinobu Y, Inoue Y, Niiro H, Kashiwagai Y, Harashima S, Tahira T, Tsukamoto
    • Journal Title

      The American Journal of the Medical Sciences

      Volume: 343(3) Pages: 210-4

    • Peer Reviewed
  • [Journal Article] Kitaba S, Matsui S, Iimuro E, Nishioka M, Kijima A, Umegaki N, Murota H, Katayama I2011

    • Author(s)
      Kitaba S, Matsui S, Iimuro E, Nishioka M, Kijima A, Umegaki N, Murota H, Katayama I
    • Journal Title

      Link between Dry Skin and Autoimmune Anhidrosis

      Volume: 60(3) Pages: 387-91

    • Peer Reviewed
  • [Journal Article] Vorner type palmoplantar keratoderma : novel KRT9 mutation associated with knuckle pad-like lesion and recurrent mutation causing digital mutilation2011

    • Author(s)
      Umegaki N, Nakano H, Tamai K, Mitsuhashi Y, Akasaka E, Sawamura D, Katayama I
    • Journal Title

      Br J Dermatol

      Volume: 165(1) Pages: 199-201

    • Peer Reviewed
  • [Journal Article] PDGFR alpha-positive cells in bone marrow are mobilized by high mobility group box 1(HMGB1) to regenerate injured epithelia2011

    • Author(s)
      Tamai K, Yamazaki T, Chino T, Ishii M, Otsuru S, Kikuchi Y, Iinuma S, Saga K, Nimura K, Shimbo T, Umegaki N, Katayama I, Miyazaki J, Takeda J, McGrath JA, Uitto J, Kaneda Y
    • Journal Title

      Proc Natl Acad Sci

      Volume: 108(16) Pages: 6609-14

    • Peer Reviewed
  • [Journal Article] A case of bullous pemphigoid exacerbated by irradiation after breast conservative radiotherapy2011

    • Author(s)
      Isohashi F, Konishi K, Umegaki N, Tanei T, Koizumi M, Yoshioka Y
    • Journal Title

      Jpn J Clin Oncol

      Volume: 41(6) Pages: 811-3

    • Peer Reviewed
  • [Journal Article] A case of giant squamous cell carcinoma of the buttock possibly arose from syringocystadenoma and invaded to the rectum2011

    • Author(s)
      Nishioka M, Tanemura A, Yamanaka T, Umegaki N, Tani M, Katayama I, Takemasa I, Sekimoto M, Tomita K, Tamai N
    • Journal Title

      J Skin Cancer

      Volume: online journal Pages: 21340

    • Peer Reviewed
  • [Journal Article] Clinical implications of leukocytapheresis using a centrifugal cell separator for steroid-resistant pyoderma gangrenosum associated with inflammatory bowel disease2010

    • Author(s)
      Hanafusa T, Azukizawa H, Umegaki N, TaniM, Yamaguchi Y, Katayama I
    • Journal Title

      J Dermatol

      Volume: 38(5) Pages: 507-10

    • Peer Reviewed
  • [Journal Article] Relation between the expression levels of thePOU transcription factors Skn-1a and Skn-1n and keratinocyte differentiation2010

    • Author(s)
      Takemoto H, Tamai K, Akasaka E, Rokunohe D, Takiyoshi N, Umegaki N, Nakajima K, Aizu T, Kaneko T, Nakano H, Sawamura D
    • Journal Title

      J Dermatol Sci

      Volume: 60(3) Pages: 203-5

    • Peer Reviewed
  • [Journal Article] Impact of sedative and non-sedative antihistamineson the impaired productivity and quality of life in patients with pruritic skin diseases2010

    • Author(s)
      Murota H, Kitaba S, Tani M, Wataya-Kaneda M, Azukizawa H, Tanemura A, Umegaki N, Terao M, Kotobuki Y, Katayama I
    • Journal Title

      Allergol Int

      Volume: 59(4) Pages: 345-54

    • Peer Reviewed
  • [Journal Article] Good' s syndrome(hypogammaglobulinemia with thymoma) presenting intractable opportunistic infections and hyperkeratotic lichen planus2010

    • Author(s)
      Hanafusa T, Umegaki N, Yamaguchi Y, Katayama I
    • Journal Title

      J Dermatol

      Volume: 37(2) Pages: 171-4

    • Peer Reviewed
  • [Journal Article] 肛門病変を契機に診断した直腸肛門部悪性黒色腫の1例2010

    • Author(s)
      中森利枝、西村由佳理、梅垣知子、谷守、種村篤、片山一朗、濱野梨絵、竹政伊知郎、関本貢嗣
    • Journal Title

      皮膚の科学

      Volume: 9(3) Pages: 244-249

    • Peer Reviewed
  • [Presentation] Investigation of roles and mechamisims of karyopherin alpha2 in keratinocyte proliferative disorders2010

    • Author(s)
      Noriko Umegaki, Katsuto Tamai, Keisuke Nimura, Satoshi Serada, Tetsuji Naka, Takehiko Yamazaki, Hajime Nakano, Yasufumi Kaneda and Ichiro Katayama
    • Organizer
      40^<th> ESDR
    • Place of Presentation
      ヘルシンキ,フィンランド
    • Year and Date
      2010-09-08
  • [Presentation] Voerner型掌蹠角化症の遺伝子変異解析と病因論的意義2010

    • Author(s)
      梅垣知子、中野創、吉良正浩、澤村大輔、片山一朗
    • Organizer
      第109回日本皮膚科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-16

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Published: 2013-07-31  

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