2011 Fiscal Year Final Research Report
Analysis and regulation of proliferative and migratory capacities of epidermal keratinocytes
| Project/Area Number |
22791080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Ehime University |
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Principal Investigator |
NANBA Daisuke 愛媛大学, 上級研究員センター, 講師 (10380255)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 皮膚炎症・再生学 / 表皮角化幹細胞 |
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| Research Abstract |
We examined the association of proliferative and migratory capacities of human cultured epidermal keratinocytes and found that proliferative capacity was positively correlated with migratory capacity in keratinocytes. We also found that a kind of integrin was involved in migratory capacity of proliferative keratinocytes and that a cell behavior generated collective dynamics in the keratinocyte colony. This result leads to understanding the collective behaviors of cells with higher proliferative capacity including stem cells and tumor cells.
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