2011 Fiscal Year Final Research Report
Contribution to cutaneous immunological diseases by new regulatory B cells
| Project/Area Number |
22791099
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
NAKASHIMA Hiroko 独立行政法人国立国際医療研究センター, 皮膚科, 医師 (30549910)
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| Project Period (FY) |
2010 – 2011
|
| Keywords | CD22 / 制御性B細胞 / 接触皮膚炎 |
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| Research Abstract |
CD22-/-mice showed delayed recovery from CHS reactions compared with wild type mice. Our current study reveals a defect in survival or retention in activated CD22-/-peritoneal B-1 cells and a regulatory role of peritoneal B-1a cells in CHS. Comparing with CHS in CD19-/-mice revealed that peritoneal B-1a cells are likely to suppress the late remission phase as "regulatory B cells". CD22 deficiency results in disturbed CHS remission by impaired retention or survival of peritoneal B-1a cells that migrate into lymphoid organs.
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