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2011 Fiscal Year Final Research Report

Mechanisms underlying effects of BDNF and antidepressants on microglia ; Possible role of TRPC channels(MIZOGUCHI YOSHITO)

Research Project

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Project/Area Number 22791128
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionSaga University

Principal Investigator

MIZOGUCHI Yoshito  佐賀大学, 医学部, 講師 (60467892)

Project Period (FY) 2010 – 2011
Keywordsうつ病 / BDNF / ミクログリア
Research Abstract

In rodent microglial cells, sustained activation of SOCE, possibly mediated by TRPC3 channels, occurred after brief BDNF application and contributed to the maintenance of sustained[ Ca^<2+>] i elevation. BDNF acutely upregulates the surface expression of TRPC3 channels in rodent microglia. In addition, RT-PCR and immunocytochemical techniques revealed that TRPC3 channels are highly expressed in rodent microglial cells.

  • Research Products

    (12 results)

All 2012 2011 2010

All Journal Article (9 results) Presentation (3 results)

  • [Journal Article] The effect of oral presentation on salivary 3-methoxy-4-hydroxy-phenylglycol(MHPG) and cortisol concentrations in training doctors : a preliminary study.2012

    • Author(s)
      Mizoguchi Y, Sakami A, Imamura Y, Tsuruta T, Egami M, Yamada S
    • Journal Title

      Endocrine

      Volume: (in press)

  • [Journal Article] Neuroinflammation in schizophrenia especially focused on the role of microglia2012

    • Author(s)
      Monji A, Kato TA, Mizoguchi Y, Horikawa H, Seki Y, Kasai M, Yamauchi Y, Yamada S, Kanba S
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: (in press)

  • [Journal Article] 神経炎症の観点よりみたアルツハイマー病の病態生理とその治療2012

    • Author(s)
      門司晃、溝口義人、山田茂人
    • Journal Title

      分子精神医学

      Volume: 12(1) Pages: 9-13

  • [Journal Article] Baseline saliva level of 3-methoxy-4-hydroxyphenylglycole(MHPG) associates with a consequent cognitive decline in non-demented elderly subjects : three-years follow-up study2012

    • Author(s)
      Watanabe I, Li GY, Imamura Y, Nabeta H, Kunitake Y, Ishii H, Haraguchi M, Furukawa Y, Tateishi H, Kojima N, Mizoguchi Y, Yamada S
    • Journal Title

      Psychiatry Res

      Volume: 195(3) Pages: 125-8

  • [Journal Article] Possible role of BDNF-induced microglial intracellular Ca(2+) elevation in the pathophysiology of neuropsychiatric disorders.2011

    • Author(s)
      Mizoguchi Y, Monji A, Kato TA, Horikawa H, Seki Y, Kasai M, Kanba S, Yamada S
    • Journal Title

      Mini Rev Med Chem

      Volume: 11 Pages: 575-81

  • [Journal Article] Anti-Inflammatory properties of antipsychotics via microglia modulations : are antipsychotics a' fire extinguisher' in the brain of schizophrenia?2011

    • Author(s)
      Kato TA, Monji A, Mizoguchi Y, Hashioka S, Horikawa H, Seki Y, Kasai M, Utsumi H, Kanba S
    • Journal Title

      Mini Rev Med Chem

      Volume: 11 Pages: 565-74

  • [Journal Article] Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate(PMA)-stimulated microglia in vitro : implication for antioxidative psychotropic actions via microglia2011

    • Author(s)
      Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S
    • Journal Title

      Schizophr Res

      Volume: 129(2-3) Pages: 172-82

  • [Journal Article] Inhibitory effects of SSRIs on IFN-γinduced microglial activation through the regulation of intracellular calcium2011

    • Author(s)
      Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Ohkuri T, Gotoh L, Yonaha M, Ueda T, Hashioka S, Kanba S
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 34(7) Pages: 1306-16

  • [Journal Article] Lewis DA(2010) Development of cannabinoid 1 receptor protein and messenger RNA in monkey dorsolateral prefrontal cortex2011

    • Author(s)
      Eggan SM*, Mizoguchi Y*, Stoyak SR
    • Journal Title

      Cereb Cortex

      Volume: 20(5) Pages: 1164-74

  • [Presentation] SSRI potentiates BDNF-induced microglial intracellular Ca^<2+> elevation Society for Neuroscience2011

    • Author(s)
      Mizoguchi Y et al
    • Organizer
      41st Annual Meeting
    • Place of Presentation
      Washington Convention Center
    • Year and Date
      2011-11-15
  • [Presentation] 精神疾患におけるミクログリアの役割2011

    • Author(s)
      神庭重信ら
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-09-15
  • [Presentation] Possible role of BDNF-induced microglial intracellular Ca^<2+> elevation in the pathophysiology of neuropsychiatric disorders2010

    • Author(s)
      Mizoguchi Y et al
    • Organizer
      40th annual meeting of the Society for Neuroscience 2010 in San Diego
    • Place of Presentation
      San Diego Convention Center
    • Year and Date
      2010-11-17

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Published: 2013-07-31  

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