2011 Fiscal Year Final Research Report
Studies about the combination of radiotherapy, hyperthermia, and a radiosensitizer
| Project/Area Number |
22791208
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
TAKAGI Masaru 札幌医科大学, 医学部, 特任助教 (10404716)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 放射線治療生物学 |
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| Research Abstract |
Gimeracil is a component of TS-1, an anti-cancer drug. Gimeracil enhanced cell-killing effects of camptothecin(CPT), 5-Fluorouracil(5-FU), and hydroxyurea. Combination of Gimeracil and CPT or 5-FU sensitized radiation more effectively than each modality alone. Gimeracil also enhanced heat sensitivity at 42℃or more. Combination of Gimeracil and heat sensitized radiation more than each modality alone did.
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Research Products
(4 results)
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[Journal Article] Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination2011
Author(s)
Sakata K, Someya M, Matsumoto Y, Tauchi H, Kai M, Toyota M, Takagi M, Hareyama M, Fukushima M
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Journal Title
Cancer Sci
Volume: 102(9)
Pages: 1712-1716
Peer Reviewed
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