2012 Fiscal Year Final Research Report
The establishment of a high-pressure gas preservation method, and the elucidation of mechanism.
| Project/Area Number |
22791266
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Tokyo Medical University (2012)
National Research Institute for Child Health and Development (2010-2011) |
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Principal Investigator |
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| Research Collaborator |
LI Xiao-kong 国立成育医療研究センター研究所, RI 管理室, 室長 (60321890)
INUBUSHI Masayuki 放射線医学総合研究所, 分子イメージング研究センター, 研究員 (70399830)
NAITO Munekazu 東京医科大学, 医学部, 講師 (10384984)
HIRAI Shuichi 東京医科大学, 医学部, 講師 (70516054)
ITOH Masahiro 東京医科大学, 医学部, 教授 (00232471)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 移植外科学 / 臓器保存 |
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| Research Abstract |
We demonstrated that exposure of organs into high-pressure CO and O2-mixed gas without immersion in stock solution leads to the maximum cell-protective effects of gas for preservation. This result is important to show the scientific evidenceand apply for clinical cases. In addition, we succeeded in rat limb preservation for one-week by using high-pressure CO and O2-mixed gas. The result indicates that high-pressure CO and O2-mixed gas is widely useful to organ preservation.
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[Remarks] (1) 畑山 直之、ラット摘出心臓による COを用いた高圧乾燥保存法の保存限界とメカニズム、第37回日本臓器保存生物医学会学術集会、2010/11/19-20、新潟学会賞受賞
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[Remarks] (2)畑山 直之、 臓器保存におけるメディカルガスの可能性～一酸化炭素(CO)と酸素(O2)を用いた高圧保存法～、第39回日本臓器保存生物医学会学術集会2012/11/16-17、福島会長賞受賞
