2011 Fiscal Year Final Research Report
The elucidation of new immunity Paragram Treg/Th17 balance in the gastrointestinal carcinoma
| Project/Area Number |
22791296
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
IIDA Takeshi 和歌山県立医科大学, 医学部, 学内助教 (30453187)
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| Project Period (FY) |
2010 – 2011
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| Keywords | Th17 / Treg / 腫瘍 / IL-17 / Foxp3 |
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| Research Abstract |
In the examination of the tumor growth curve in the mouse in vivo subcutaneous tumor model, in the mIL-17A-shRNA group, it significantly showed tumor growth depression effect as compared with the PBS group of the control SNC group.
It was suggested that IL-17 acted as a tumor growth factor in the tumor microenvironment.
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[Journal Article] Tumor-infiltrating CD4+Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer2011
Author(s)
Iida T, Iwahashi M, Katsuda M, Ishida K, Nakamori M, Nakamura M, Naka T, Ojima T, Ueda K, Hayata K, Nakamura Y, Yamaue H
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Journal Title
Oncol Rep
Volume: 25(5)
Pages: 1271-7
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