2011 Fiscal Year Final Research Report
Development of new therapeutic for epilepsy using convection enhanced delivery
| Project/Area Number |
22791330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 医療・福祉 / 外科 / 神経科学 / 脳神経疾患 |
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| Research Abstract |
This study was designed for development of new therapeutics of intractable epilepsy. Convection-enhanced delivery (CED)is the method for delivering drugs from thin catheter tip directly into brain parenchyma with slow infusion rate. We performed CED of antiepileptic drug Levetiracetam to the hippocampus of rats with acute seizures. The Levetiracetam CED significantly reduced the occurrence and the duration of seizures. The animals showed no neurological deficits after the treatment. CED may be promising as a less invasive surgical treatment of epilepsy.
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