Neuroprotective mechanism of bone marrow mesenchymal stem cells via immune regulation of brain

2012 Fiscal Year Final Research Report

• Project/Area Number: 22791357
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Showa University
• Principal Investigator: OHTAKI Hirokazu 昭和大学, 医学部, 助教 (20349062)
• Project Period (FY): 2010 – 2012
• Keywords: 実験脳外科学

Research Abstract

It has been suggested that mesenchymal stem cells (MSCs) suppress neuronal injury by collaboration with microglial cells. However, there are still unclear that the effects are direct regulation. In present study, we determined effect of hMSCs on in vitro mixed culture and in vivo spinal cord injury (SCI) model. Resulting, hMSCs decreased an inflammation marker, NO in the cell number dependent fashion. Moreover, implantation of the hMSCs one day after SCI decreased significantly motor deficit and injury volume.

Research Products

• [Journal Article] Establishment and Characterization of Primary Adult Microglial Culture in Mice (2013)
  • Author(s): Ohtaki H, Tsumuraya T, Song D, Sato A, Ohara K, Miyamoto K, Nakano H, Kiriyama K, Dohi K, Hiraizumi H, Matsunaga M, Shioda S
  • Journal Title: Acta Neurochir Suppl Volume: 118 Pages: 49-54
  • DOI: doi:10.1007/978-3-7091-1434-6_8.
  • Peer Reviewed
• [Journal Article] Edaravone Increases Regional Cerebral Blood Flow After Traumatic Brain Injury in Mice (2013)
  • Author(s): Miyamoto K, Ohtaki H, Dohi K, Tsumuraya T, Nakano H, Kiriyama K, Song D, Aruga T, Shioda S
  • Journal Title: Acta Neurochir Suppl Volume: 118 Pages: 103-9
  • DOI: doi:10.1007/978-3-7091-1434-6_18.
  • Peer Reviewed
• [Journal Article] Therapeutic Time Window for Edaravone Treatment of Traumatic Brain Injury in Mice (2013)
  • Author(s): Miyamoto K, Ohtaki H, Dohi K, Tsumuraya T, Song D, Kiriyama K, Satoh K, Shimizu A, Aruga T, Shioda S
  • Journal Title: BioMed Res Int Volume: Article ID 379206
  • URL: http://dx.doi.org/10.1155/2013/379206
  • Peer Reviewed
• [Journal Article] Accumulation of autofluorescent storage material in brain is accelerated by ischemia in chloride channel 3 gene-deficient mice (2012)
  • Author(s): Ohtaki H, Ohara K, Song D, Miyamoto K, Tsumuraya T, Yofu S, Dohi K, Tanabe S, Sasaki S, Uchida S, Matsunaga M, Shioda S
  • Journal Title: J Neurosci Res Volume: 90 (11) Pages: 2163-72
  • DOI: doi:10.1002/jnr.23110
  • Peer Reviewed
• [Journal Article] Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury (2012)
  • Author(s): Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, Iwakura Y, Atsumi T, Shioda S
  • Journal Title: J Neuroinflammation Volume: 9 Pages: 65
  • DOI: doi:10.1186/1742-2094-9-65.
  • Peer Reviewed
• [Journal Article] Role of PACAP in neural stem/progenitor cell and astrocyte--from neural development to neural repair (2011)
  • Author(s): Nakamachi T, Farkas J, Watanabe J, Ohtaki H, Dohi K, Arata S, Shioda S
  • Journal Title: Curr Pharm Des Volume: 17(10) Pages: 973-84
  • Peer Reviewed
• [Journal Article] Expression and localization of the orexin-1 receptor (OX1R) after traumatic brain injury in mice (2011)
  • Author(s): Mihara Y, Dohi K, Yofu S, Nakamachi T, Ohtaki H, Shioda S, Aruga T
  • Journal Title: J Mol Neurosci Volume: 43(2) Pages: 162-8
  • DOI: doi:10.1007/s12031-010-9438-6.
  • Peer Reviewed
• [Journal Article] Early changes to oxidative stress levels following exposure to formaldehyde in ICR mice (2010)
  • Author(s): Matsuoka T, Takaki A, Ohtaki H, Shioda S
  • Journal Title: J Toxicol Sci Volume: 35(5) Pages: 721-30
  • Peer Reviewed
• [Journal Article] Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. (2010)
  • Author(s): Dohi K, Ohtaki H, Nakamachi T, Yofu S, Satoh K, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T
  • Journal Title: J Neuroinflammation Volume: 7 Pages: 41
  • DOI: doi:10.1186/1742-2094-7-41
  • Peer Reviewed
• [Journal Article] Regulation of oxidative stress by pituitary adenylate cyclase-activating polypeptide (PACAP) mediated by PACAP receptor (2010)
  • Author(s): Ohtaki H, Satoh A, Nakamachi T, Yofu S, Dohi K, Mori H, Ohara K, Miyamoto K, Hashimoto H, Shintani N, Baba A, Matsunaga M, Shioda S
  • Journal Title: J Mol Neurosci Volume: 42(3) Pages: 397-403
  • DOI: doi:10.1007/s12031-010-9350-0
  • Peer Reviewed
• [Journal Article] Cardioprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on Doxorubicin-induced cardiomyopathy in mice (2010)
  • Author(s): Mori H, Nakamachi T, Ohtaki H, Yo f u S, Sato A, Endo K, Iso Y, Suzuki H, Takeyama Y, Shintani N, Hashimoto H, Baba A, Shioda S.
  • Journal Title: Circ J. Volume: 74(6) Pages: 1183-90
  • Peer Reviewed
• [Journal Article] Nucleoprotein Diet Ameliorates Arthritis Symptoms in Mice Transgenic for Human T-Cell Leukemia Virus Type I (HTLV-1) (2010)
  • Author(s): Ohtaki H, Yofu S, Nakamachi T, Satoh K, Shimizu A, Mori H, Sato A, Iwakura Y, Matsunaga M, Shioda S
  • Journal Title: J Clin Biochem Nutr Volume: 46(2) Pages: 93-104
  • DOI: doi:10.3164/jcbn.09-61.
  • Peer Reviewed
• [Journal Article] Novel free radical monitoring in patientswith neurological emergency diseases (2010)
  • Author(s): Dohi K, Satoh K, Nakamachi T, Ohtaki H, Yofu S, Nakamura S, Shioda S, Aruga T
  • Journal Title: Acta Neurochir Suppl Volume: 106 Pages: 315-9
  • DOI: doi:10.1007/978-3-211-98811-4_59
  • Peer Reviewed
• [Journal Article] Endogenous pituitary adenylate cyclase activating polypeptide is involved in suppression of edema in the ischemic brain (2010)
  • Author(s): Nakamachi T, Ohtaki H, Yofu S, Dohi K, Watanabe J, Mori H, Sato A, Hashimoto H, Shintani N, Baba A, Shioda S
  • Journal Title: Acta Neurochir Suppl Volume: 106 Pages: 43-6
  • DOI: doi:10.1007/978-3-211-98811-4_6
  • Peer Reviewed
• [Presentation] 骨髄間葉系幹細胞の神経損傷抑制機構に関わる神経ペプチドPACAP(シンポジウム) (2013)
  • Author(s): 大滝博和、塩田清二
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 高松・香川
  • Year and Date: 20130328-30
• [Presentation] 経静脈および動脈系を介したヒト骨髄間葉系幹細胞移植によるマウス脳梗塞抑制効果の比較) (2013)
  • Author(s): 大滝博和, 宋丹丹, 宮本和幸, 宮里穂久美, 土肥謙二, 平泉裕, 塩田清二
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 高松・香川
  • Year and Date: 20130328-30
• [Presentation] Stem cell characteristics and anti-inflammation properties of hMSCs in different passages (2013)
  • Author(s): Song D, Ohtaki H, Tsumuraya T, Sato A, Hiraizumi Y, Inoue T, Shioda S
  • Organizer: 第118回日本解剖学会総会・全国学術集会
  • Place of Presentation: 高松・香川
  • Year and Date: 20130328-30
• [Presentation] The anti-inflammatory property of human bone marrow-derived mesenchymal stem cells is preserved in late-passage cultures (2013)
  • Author(s): Ohtaki H, Song D, Tsumuraya T, Miyamoto K, Shibato J, Rakwal R, Xu Z, Inoue T, Shioda S
  • Organizer: 6th International Symposium on mesenchymal stem/progenitor cells
  • Place of Presentation: College Station, TX, USA
  • Year and Date: 2013-05-03
• [Presentation] Interleukin-1 (IL-1) may contribute to develop classical and alternative activation of microglia/macrophages after spinal cord injury (2012)
  • Author(s): Ohtaki H, Sato A, Tsumuraya T, Song D, Miyamoto K, Ohara K, Asano M, Iwakura Y, Atsumi T, Shioda S
  • Organizer: 11th International Society of NeuroImmunology Congress
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 20121104-08
• [Presentation] Oxidant and Antioxidant Levels During Brain Hypothermia Therapy After Cardiopulmonary Resuscitation 2012 (2012)
  • Author(s): Dohi K, Miyamoto K, Satoh K, Nakamura S, Ohtaki H, Shioda S, Aruga T
  • Organizer: アメリカ心臓病学会
  • Place of Presentation: Chicago,USA
  • Year and Date: 20121104-08
• [Presentation] Activated microglia induced animal model of Parkinson's disease, but not in IL-1 knockout mouse (2012)
  • Author(s): Tanaka S, Ishii A, Ohtaki H, Shioda S, Yoshida T. Numazawa S
  • Organizer: 8th FENS
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20121104-08
• [Presentation] EFFECT OF ADULT HUMAN BONE MARROW MESENCHYMAL STEM CELLS TRANSPLANTED INTO INTRA-ARTERIAL AND INTRA-VENOUS AFTER ISCHEMIA (2012)
  • Author(s): Ohtaki H, Song D, Dohi K, Miyamoto K, Tsumuraya T, Miyazato M, Shioda S
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20121013-17
• [Presentation] ストレス緩和の神経科学(シンポジウム) (2012)
  • Author(s): 塩田 清二,中町 智哉,大滝 博和,荒田 悟,小川 哲郎
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 20120918-21
• [Presentation] Protective effect of a nucleoprotein diet in a mouse model of MPTP-induced Parkinson's disease (2012)
  • Author(s): Kiriyama K, Ohtaki H, Kobayashi N, Satoh K, Matsunaga M, Shioda S
  • Organizer: The Tenth International Catecholamine Symposium (XICS)
  • Place of Presentation: Pacific Grove, CA, USA
  • Year and Date: 20120909-13
• [Presentation] COMPARISON OF INTRA-ARTERIAL AND INTRA-VENOUS TRANSPLANTATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS SUPPRESSED ISCHEMIC NEURONAL CELL DEATH (2012)
  • Author(s): Ohtaki H, Song D, Nakano H, Tsumuraya T, Miyamoto K, Miyazato M, Hiraizumi Y, Shioda S
  • Organizer: International Society for Stem cell Research (ISSCR) 10th Annual Meeting
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20120613-16
• [Presentation] STEM CELL CHARACTERISTICS OF HUMAN MSCS IN DIFFERENT PASSAGES (2012)
  • Author(s): Song D, Ohtaki H, Tsumuraya T, Nakano H, Hiraizumi Y, Inoue T, Shioda S
  • Organizer: International Society for Stem cell Research (ISSCR) 10th Annual Meeting
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20120613-16
• [Presentation] 神経損傷モデルにおける骨髄幹細胞による神経再生 (2012)
  • Author(s): 大滝博和
  • Organizer: 第117回日本解剖学会総会・全国学術集会 (招待講演)
  • Place of Presentation: 甲府,山梨
  • Year and Date: 20120326-28
• [Presentation] ヒト間葉系幹細胞移植による脊髄損傷の改善過程における下垂体アデニル酸シクラーゼ活性化ポリペプチドの関与の可能性 (2012)
  • Author(s): 圓谷 智海、大滝博和、宋 丹丹、中町 智哉、佐藤 敦 、平 泉 裕、渥美 敬、塩田 清二
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府,山梨
  • Year and Date: 20120326-28
• [Presentation] マウス頭部外傷モデルにおけるエダラボンの神経保護作用についての検討 (2012)
  • Author(s): 宮本和幸, 大滝博和, 土肥謙二, 佐藤和恵, 有賀徹, 塩田清二
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府,山梨
  • Year and Date: 20120326-28
• [Presentation] 核タンパクの摂取はパーキンソン病様モデル動物の症状を予防する (2012)
  • Author(s): 桐山恵介、大滝博和、小林夏季、松永政司、塩田清二
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府,山梨
  • Year and Date: 20120326-28
• [Presentation] PACAP誘導性の涙液分泌におけるアクアポリン5の役割 (2012)
  • Author(s): 中町智哉,会沢洋一,大滝博和,養父佐知子,関保,和田悦洋,加賀美信幸,荒田悟,新谷紀人,橋本均,馬場明道,塩田清二
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府,山梨
  • Year and Date: 20120326-28
• [Presentation] マウス頭部外傷モデルにおけるエダラボンの神経保護作用についての検討 (2012)
  • Author(s): 宮本和幸, 大滝博和, 土肥謙二, 中村俊介, 三宅康史, 塩田清二, 有賀徹
  • Organizer: 第35回日本脳神経外傷学会
  • Place of Presentation: 東京
  • Year and Date: 20120309-10
• [Presentation] Chloride channel 3遺伝子欠損マウスにおける脳虚血モデルによる脳内のAutofluorescent storage material(ASM)発現の増加に対する検討 (2012)
  • Author(s): 小原賢司,大滝博和,渥美敬,塩田清二
  • Organizer: 第5 9回昭和医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-12-01
• [Presentation] 脊髄損傷マウスに対するヒト骨髄由来間葉系幹細胞の有用性およびPACAPを介する作用機序の解明 (2012)
  • Author(s): 圓谷智海、大滝博和、渥美敬、塩田清二
  • Organizer: 第113回昭和医学会例会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-29
• [Presentation] POSSIBLE INVOLVEMENT OF PACAP ON IMPROVEMENT OF SPINAL CORD INJURY BY HUMAN MESENCHYMAL STEM CELLS (2011)
  • Author(s): Tsumuraya T, Ohtaki H, SONG T, Nakamachi T, Sato A, Hiraizumi Y, Atsumi T, Shioda S
  • Organizer: The 10th International Symposium on VIP-PACAP and Related Peptides
  • Place of Presentation: Eilat, Israel
  • Year and Date: 20111213-16
• [Presentation] PACAP stimulates the lacrimation via aquaporine 5 translocation in mouse (2011)
  • Author(s): Nakamachi T, Aizawa Y, Ohtaki H, Seki T, Wada Y, Kagami N, Arata S, Hashimoto H, Shintani N, Baba A, Farkas J, Reglodi D, Shioda S
  • Organizer: The 10th International Symposium on VIP-PACAP and Related Peptides
  • Place of Presentation: Eilat, Israel
  • Year and Date: 20111213-16
• [Presentation] The retinoprotective effect of exogenous PACAP involves a modulation of retinal microglia/macrophage (2011)
  • Author(s): Wada Y, Nakamachi T, Endo K, Seki T, Ohtaki H, Tsuchikawa D, Hori M, Farkas J, Tsuchida M, Yoshikawa A, Kagami N, Imai N, Shioda S
  • Organizer: The 10th International Symposium on VIP-PACAP and Related Peptides
  • Place of Presentation: Eilat, Israel
  • Year and Date: 20111213-16
• [Presentation] Edaravone suppressed secondary neuronal cell damage after traumatic brain injury in mice (2011)
  • Author(s): Miyamoto K, Ohtaki H, Dohi K, Song D, Tsumuraya T, Nakano H, Kiriyama K, Kageyama H, Aruga T, Shioda S
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20111112-16
• [Presentation] Interleukin-1 gene deficient mice modulate microglial activation after spinal cord injury Neuroscience (2011)
  • Author(s): Ohtaki H, Sato A, Tsumuraya T, Song D, Nakano H, Kiriyama K, Miyamoto K, Shioda S
  • Place of Presentation: Washington DC, USA
  • Year and Date: 20111112-16
• [Presentation] Therapeutic time window of edaravone on traumatic brain injury in mice (2011)
  • Author(s): Miyamoto K, Ohtaki H, Dohi K, Song D, Tsumuraya T, Nakano H, Kiriyama K, Aruga T, Shioda S
  • Organizer: Brain Edema 2011
  • Place of Presentation: Tokyo
  • Year and Date: 20111022-24
• [Presentation] Anti-inflammatory effect of human MSCs on global ischemia (2011)
  • Author(s): Ohtaki H, Song D, Nakano H, Miyamoto K, Tsumuraya T, Dohi K, Prockop DJ, Shioda S
  • Organizer: Brain Edema 2011
  • Place of Presentation: Tokyo
  • Year and Date: 20111022-24
• [Presentation] 核蛋白質によるパーキンソン病予防効果の検討 (2011)
  • Author(s): 小林夏季,大滝博和,宋丹丹,宮本和幸,圓谷智海,吉田武美,松永政司,塩田清二
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20110328-30
• [Presentation] 異なる継代回数における骨髄由来間葉系幹細胞の特性比較 (2011)
  • Author(s): 宋丹丹,大滝博和,小林夏季,圓谷智海,平泉裕,井上富雄,塩田清二
  • Organizer: 第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会合同大
  • Place of Presentation: 横浜
  • Year and Date: 20110328-30
• [Presentation] インターロイキン1の欠損は脊髄損傷のマイクログリア・マクロファージ活性化に影響する (2011)
  • Author(s): 大滝博和,佐藤敦,小原賢司,圓谷智海,加藤慎,宋丹丹,小林夏季,渥美敬,塩田清二
  • Organizer: 第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20110328-30
• [Presentation] Suppression of oxidative stress on PACAP might involve in the neuroprotection (2011)
  • Author(s): Ohtaki H, Miyamoto K, Tsumuraya T, Kiriyama K, Nakano H, Song D, Nakamachi T, Hiraizumi Y, Matsunaga M, Shioda S
  • Organizer: Satellite Symposium of the 20th Annual Meeting of the Israel Society for Neuroscience Basic and Clinical Research of GPCRs
  • Place of Presentation: Eilat, Israel
  • Year and Date: 2011-12-13
• [Presentation] The exogenous PACAP is possible modulator of the activation of retinal microglia/macrophage in the injured retina (2011)
  • Author(s): Wada Y, Nakamachi T, Endo K, Seki T, Ohtaki H, Tsuchikawa D, Hori M, Farkas J, Tsuchida M, Yoshikawa A, Kagami N, Imai N, Shioda S
  • Organizer: Satellite Symposium of the 20th Annual Meeting of the Israel Society for Neuroscience Basic and Clinical Research of GPCRs
  • Place of Presentation: Eilat, Israel
  • Year and Date: 2011-12-13
• [Presentation] 脊髄損傷マウスにおけるマイクログリア/マクロファージ活性化へのインターロイキン1の関与 (2011)
  • Author(s): 佐藤敦,大滝博和,小原賢司,圓谷智海,宋丹丹,渥美敬,塩田清二
  • Organizer: 第58回昭和医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-26
• [Presentation] 外傷モデルにおけるエダラボンの神経保護作用についての検討 (2011)
  • Author(s): 宮本和幸, 大滝博和, 土肥謙二, 佐藤和恵, 有賀徹, 塩田清二
  • Organizer: 第58回昭和医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-26
• [Presentation] Neuroprotection of hMSCs on CNS diseases (2011)
  • Author(s): Ohtaki H
  • Organizer: Texas A&M Invited Seminar (招待講演)
  • Place of Presentation: Temple, TX, USA
  • Year and Date: 2011-11-10
• [Presentation] 核タンパク質のパーキンソン病モデル動物に対する予防効果の検討 (2011)
  • Author(s): 桐山恵介、大滝博和、小林夏季、松永政司、塩田清二
  • Organizer: 第6回核酸・核タンパク機能性研究会学術集会 第6回核酸・核タンパク機能性研究会学術集会
  • Place of Presentation: 恵庭・北海道
  • Year and Date: 2011-08-08
• [Presentation] Human MSCs decrease nitric oxide release from microglia (2010)
  • Author(s): Ohtaki H, Song D, Kobayashi N, Dohi K, Shioda S
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20101113-17
• [Presentation] Activation of microglia lead to onset of Parkinson disease animal model (2010)
  • Author(s): Ishii A, Tanaka S, Ohtaki H, Nakamachi T, Numazawa S, Shioda S, Yoshida T
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 20101113-17
• [Presentation] Human MSCs suppress neuronal cell death after ischemia by anti-inflammation (2010)
  • Author(s): Ohtaki H, Ylostalo J, Song D, Kobayashi N, Prockop DJ, Shioda S
  • Organizer: 10th International Congress of Neuroimmunology (ISNI 2010)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20101026-30
• [Presentation] The roles of Gp91phox (NOX2) expressed in classical activated microglia after traumatic brain injury (2010)
  • Author(s): Dohi K, Ohtaki H, Kazue S, Nakamachi T, Yo f u S, Miyamoto K, Song D, Tsunawaki S, Shioda S, Aruga T
  • Organizer: 10th International Congress of Neuroimmunology (ISNI 2010)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20101026-30
• [Presentation] Interleukin-1 influence microglia/ macrophage activation after spinal cord injury in mice (2010)
  • Author(s): Sato A, Ohara K, Ohtaki H, Atsumi T, Shioda S
  • Organizer: 10th International Congress of Neuroimmunology (ISNI 2010)
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20101026-30
• [Presentation] Human MSCs modified classical activation in microglial cells (2010)
  • Author(s): Ohtaki H, Murakami T, Song D, Sato A, Dohi K, Shioda S
  • Organizer: ISSCR 8th Annual Meeting
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 20100616-19
• [Presentation] ドキソルビシン心筋症モデルマウスにおけるPACAP (pituitary adenylate cyclase-activating polypeptide)の心保護作用 (2010)
  • Author(s): 森敬善、中町智哉、大滝博和、養父佐知子、鈴木洋、獄山陽一、新谷紀人、橋本均、馬場明道、塩田清二
  • Organizer: 第6回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 20100508-09
• [Presentation] PACAPの抗酸化誘導作用と加齢性神経障害における役割 (2010)
  • Author(s): 中町智哉、大滝博和、養父佐知子、加賀美信幸、荒田悟、新谷紀人、橋本均、馬場明道、塩田清二
  • Organizer: 第6回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 20100508-09
• [Patent(Industrial Property Rights)] アミロイド線維の形成を伴う神経変性疾患の予防・改善薬 (2011)
  • Inventor(s): 塩田清二、大滝博和、小林夏季
  • Industrial Property Rights Holder: フォーデイズ株式会社
  • Industrial Property Number: 特許出願2011-3250
  • Filing Date: 2011-02-17