2011 Fiscal Year Final Research Report
Evaluation of RANKL reverse signaling as therapeutic targets for osteoporosis
| Project/Area Number |
22791364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HONMA Masashi 東京大学, 医学部附属病院, 助教 (60401072)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 骨・軟骨代謝学 |
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| Research Abstract |
Microtubules are necessary for RANKL translocation to the osteoblastic cell surface and Rac1/Cdc42-IQGAP1-CLIP170 are indicted to be involved in the reconstruction of microtubules towards the stimulated area. Moreover, mTORC2 is indicated to be activated in response to RANK stimulation and regulate Racc1/Cdc42 activation.
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