Efficient derivation of osteoprogenitor cells from induced pluripotent stem cells for bone regeneration

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791379
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: LEE Sangyang 神戸大学, 医学部附属病院, 特定助教 (40533732)
• Project Period (FY): 2010 – 2011
• Keywords: 四肢機能再建学 / 再生医療

Research Abstract

The novel direct-plating method described here provides a significant technical advance over conventional methods of iPSC. induced osteoprogenitor cells by avoiding the embryonic body formation that often leads to heterogeneous and unpredictable osteogenic differentiation. Because of simplicity, our novel direct-plating method could be amenable to large-scale production of osteoprogenitor cells for bone regeneration.

Research Products

• [Presentation] Efficient deriva tion of osteoprogenitor cells from ind uced pluripotent stem cell for bone r egeneration (2012)
  • Author(s): Dogaki Y, Lee SY, Niikura T, Koh A, Koga T, Okumachi E, Nishida K, Kur oda R, Kurosaka, M.
  • Organizer: 1^<st> AO Trauma Asia Pa cific Scientific Congress
  • Place of Presentation: Hong Kong, Chinna
  • Year and Date: 20120511-12
• [Presentation] Efficient differentiation and characterization of murine ind uced pluripotent stem cell-derived os teoprogenitor cells without embryoid body formation (2012)
  • Author(s): Dogaki Y, Lee SY, Niikura T, Koh A, Koga T, Okumachi E, Kakutani K, Hirata H, Nishida K, Kuroda R, Kurosaka M.
  • Organizer: 58^<th> Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: San Francisco, CA, USA.
  • Year and Date: 20120204-07