2011 Fiscal Year Final Research Report
The effect of human mesenchymal stem cell and risedronate on TNF-alpha-induced osteoclast differentiation
| Project/Area Number |
22791384
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
FUJITA Hirofumi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20423288)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 破骨細胞 / 間葉系幹細胞 / ビスホスフォネート |
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| Research Abstract |
We investigated the effect of human bone marrow mesenchymal stem cell(hMSC) and bisphosphonate on inflammatory cytokine-induced osteoclast differentiation. Our findings showed that osteoclast differentiation by TNF-alpha was suppressed by hMSC and the suppression was inhibited by bisphosphonate.
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[Journal Article] Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells2011
Author(s)
Ogino T, Kobuchi H, Munetomo K, Fujita H, Yamamoto M, Utsumi T, Inoue K, Shuin T, Sasaki J, Inoue M, Utsumi K
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Journal Title
Mol Cell Biochem
Volume: 358(1-2)
Pages: 297-307
Peer Reviewed
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[Journal Article] Effect of risedronate on receptor activator of NF-κB ligand and apoptosis in mesenchymal stem cells2011
Author(s)
Fujita H, Kurokawa K, Ogino T, Ono M, Yamamoto M, Oka T, Nakanishi T, Kobayashi N, Tanaka N, Ogawa T, Suzaki E, Utsumi K, Sasaki J
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Journal Title
Basic Clin Pharmacol Toxicol
Volume: 109(2)
Pages: 78-84
DOI
Peer Reviewed
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