Elucidation of the mechanism of the spinal cord injury by q-space imaging

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791401
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Clinical research Center, National Hospital Organization Murayama Medical Center (2011); Keio University (2010)
• Principal Investigator: FUJIYOSHI Kanehiro 独立行政法人国立病院機構村山医療センター(臨床研究センター), 整形外科, 医員 (80365303)
• Project Period (FY): 2010 – 2011
• Keywords: 脊髄損傷 / MRI / コモンマーモセット / 髄鞘 / 脱髄 / 再髄鞘化 / 神経幹細胞移植 / q-spaceイメージング

Research Abstract

Here we developed the "Myelin map," an enhanced myelin visualization method based on q-space MR imaging. This method visualizes the highly restricted diffusion of water molecules in myelin sheaths. Myelin maps accurately depicted the poor myelination in myelin-deficient mice, the demyelination/remyelination in marmoset chemical SCI, and the remyelination after allogeneic NS/PC transplantation in marmosets. Myelin maps have an unparalleled ability to visualize demyelination/remyelination and the potential for immediate clinical application as a powerful tool for researchers and clinicians examining diseases of the central nervous system(CNS).

Research Products

• [Journal Article] Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy (2012)
  • Author(s): Nakamura M, Fujiyoshi K, Tsuji O, Konomi T, Hosogane N, Watanabe K, Tsuji T, Ishii K, Momoshima S, Toyama Y, Chiba K, Matsumoto M
  • Journal Title: J Neurosurg Spine
  • Peer Reviewed
• [Journal Article] Long-term surgical outcomes of spinal meningiomas (2012)
  • Author(s): Nakamura M, Tsuji O, Fujiyoshi K, Hosogane N, Watanabe K, Tsuji T, Ishii K, Toyama Y, Chiba K, Matsumoto M
  • Journal Title: Spine(Phila Pa 1976) Volume: 37(10) Pages: E617-23
  • Peer Reviewed
• [Journal Article] Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury (2011)
  • Author(s): Kitamura K, Fujiyoshi K, Yamane J, Toyota F, Hikishima K, Nomura T, Funakoshi H, Nakamura T, Aoki M, Toyama Y, Okano H, Nakamura M
  • Journal Title: PLoS One Volume: 6(11) Pages: e27706
  • Peer Reviewed
• [Journal Article] Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord (2011)
  • Author(s): Yasuda A, Tsuji O, Shibata S, Nori S, Takano M, Kobayashi Y, Takahashi Y, Fujiyoshi K, Hara CM, Miyawaki A, Okano HJ, Toyama Y, Nakamura M, Okano H
  • Journal Title: Stem Cells Volume: 29(12) Pages: 1983-94
  • Peer Reviewed
• [Journal Article] Cervical intramedullary ependymoma masquerading as cervical spondylotic myelopathy on MRI analysis (2011)
  • Author(s): Tsuji O, Nakamura M, Fujiyoshi K, Ishii K, Watanabe K, Hosogane N, Tsuji T, Momoshima S, Toyama Y, Chiba K, Matsumoto M
  • Journal Title: J Orthop Sci
  • Peer Reviewed
• [Journal Article] Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice (2011)
  • Author(s): Nori S, Okada Y, Yasuda A, Tsuji O, Takahashi Y, Kobayashi Y, Fujiyoshi K, Koike M, Uchiyama Y, Ikeda E, Toyama Y, Yamanaka S, Nakamura M, Okano H
  • Journal Title: Proc Natl Acad Sci USA Volume: 108(40) Pages: 16825-30
  • Peer Reviewed
• [Journal Article] Cell therapy for spinal cord injury by neural stem/progenitor cells derived from iPS/ES cells (2011)
  • Author(s): Tsuji O, Miura K, Fujiyoshi K, Momoshima S, Nakamura M, Okano H
  • Journal Title: Neurotherapeutics Volume: 8(4) Pages: 668-76
  • Peer Reviewed
• [Journal Article] Long-term surgical outcomes of idiopathic spinal cord herniation (2011)
  • Author(s): Nakamura M, Fujiyoshi K, Tsuji O, Watanabe K, Tsuji T, Ishii K, Matsumoto M, Toyama Y, Chiba K
  • Journal Title: J Orthop Sci Volume: 16(4) Pages: 347-51
  • Peer Reviewed
• [Presentation] In vino Myelin map based on non-Gaussian diffusion distribution elucidated remyelination after cell transplantation in spinal cord injury primates (2012)
  • Author(s): Kanehiro Fujiyoshi, Tsunehiko Konomi, Osahiko Tsuji, Keigo Hikishima, Akio Iwanami, Morio Matsumoto, Hideyuki Okano, Yoshiaki Toyama, Kazuhiro Chiba, Masaya Nakamura
  • Organizer: 3^<rd> Annual Meeting of Cervical Spine Research Society
  • Place of Presentation: Asia Pacific Section Fukuoka
  • Year and Date: 20120421-22
• [Presentation] A novel in vivo myelin MR imaging elucidated the mechanism of spinal cord injury (2011)
  • Author(s): K Fujiyoshi, T Konomi, O Tsuji, K Hikishima, S Momoshima, M Matsumoto, K Chiba, H Okanno, Y Toyama, M Nakamura
  • Organizer: Cervical Spine Research Society 39^<th> Annual Meeting Scottsdale
  • Place of Presentation: Arizona
  • Year and Date: 2011-12-08
• [Presentation] 脊髄円錐部に発生した軟膜下脂肪腫において手術を施行した1例 (2011)
  • Author(s): 藤吉兼浩,中村雅也,辻収彦,千葉一裕,戸山芳昭,松本守雄
  • Organizer: 脊髄円錐部に発生した軟膜下脂肪腫において手術を施行した1例
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-19
• [Presentation] q-space MR imaging depict demyelination after spinal cord injury in non-human primate (2011)
  • Author(s): K Fujiyoshi, O Tsuji, T Konomi, K Hikishima, M Yamada, S Momoshima, H Okanno, Y Toyama, M Nakamura
  • Organizer: Neuroscience2011
  • Place of Presentation: Washington, DC
  • Year and Date: 2011-11-13
• [Presentation] 非侵襲的髄鞘可視法"Myelin map"の精度検証と臨床応用 (2011)
  • Author(s): 藤吉兼浩,許斐恒彦,辻収彦,疋島啓吾,松本守雄,千葉一裕,百島祐貴,岡野栄之,戸山芳昭,中村雅也
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 群馬
  • Year and Date: 2011-10-21
• [Presentation] 拡散テンソルトラクトグラフィを用いた損傷脊髄における投射路の可視化 (2011)
  • Author(s): 藤吉兼浩,町田正文,塩田匡宣,竹光正和,福田健太郎,八木満,飯塚慎吾,名越慈人,五十嵐一峰,臼井宏
  • Organizer: 第65回国立病院総合医学会
  • Place of Presentation: 岡山
  • Year and Date: 2011-10-08
• [Presentation] QSIの脊髄再生医療への応用 (2011)
  • Author(s): 藤吉兼浩,疋島啓吾,百島祐貴,小牧裕司,山田雅之,八木一夫,許斐恒彦,辻収彦,戸山芳昭,岡野栄之,中村雅也
  • Organizer: 第39回日本磁気共鳴医学会大会「Q space imaging/diffusional kurtosis imaging」
  • Place of Presentation: 福岡
  • Year and Date: 2011-09-29
• [Presentation] 脊髄損傷モデルおよび再生過程における軸索および髄鞘の可視化の試み (2011)
  • Author(s): 藤吉兼浩
  • Organizer: 神経組織の成長・再生・移植研究会第26回学術集会
  • Place of Presentation: 東京医科大学病院
  • Year and Date: 2011-06-25
• [Presentation] 脊髄損傷における拡散MRI (2011)
  • Author(s): 藤吉兼浩
  • Organizer: 第6回日本分子イメージング学会
  • Place of Presentation: 神戸
  • Year and Date: 2011-05-27