2012 Fiscal Year Final Research Report
Proteomics analyses of bone and soft tissue tumors
| Project/Area Number |
22791405
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | プロテオミクス / 骨軟部腫瘍 |
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| Research Abstract |
We conducted proteomics approaches to discover novel biomarkers of bone and soft tissue tumors. Also, we tried to validate possibilities of the biomarker and the functions of the proteins in the each tumors for developing clinical applications. In this project, we focused on GIST, Ewing sarcoma, synovial sarcoma, osteosarcoma as well as giant cell tumor. In the results, we identified several proteins was candidates of biomarkers and have succeeded to confirm the power of biomarker in the each larger scale validation using multi-institutional cohorts. Also we also illuminated the functions of these proteins in the each tumors based on cell proliferation, interactive proteins, regulated proteins..
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