2012 Fiscal Year Final Research Report
The study of sepsis induced urine concentrating mechanism failure and body fluid maintenance based mainly on sodium administration
| Project/Area Number |
22791412
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | ナトリウム / アルドステロン / 副腎不全 / 循環血液量 / 敗血症 |
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| Research Abstract |
Adrenalectomized rats were assigned to three groups. ADX group was administered oral distilled water. NS group was administered oral saline and ALD group was administered aldosterone by osmotic mini pump. And part of the each group was administered lipopolysaccharide. In all of the groups, circulating blood volume, urine volume and urine osmolality were measured. And tissue sodium concentration of the hole, cortex, outer medulla and inner medulla of the kidney of the all groups were measured. Expression of tonicity-responsive enhancer binding protein in the kidney tissue was also measured by immunohistochemical staining. Tissue sodium concentration of the kidney was decreased in adrenal failure and which was slightly attenuated by oral sodium administration. Only aldosterone administration maintained the urine osmolality by the preservation of the kidney tissue sodium concentration.
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