2011 Fiscal Year Final Research Report
Study on analgesic mechanism of GCH1 inhibitor
| Project/Area Number |
22791425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | テトラヒドロビオプテリン / グアニル酸シクロヒドロラーゼ1 / 痛覚伝達 / 後根神経節 / アセチルコリン / 神経障害痛のラットモデル / pChAT |
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| Research Abstract |
GCH1 is the first and rate-limiting enzyme in the biosynthetic pathway of tetrahydrobiopterin(BH4), an important cofactor for the synthesis of several modulator in pain neurotransmission. Recently, the importance of GCH1 as pain marker has been recognized. Here, the role of BH4 has been investigated in the DRG of rat model of pain and in naive rat treated with cholinergic agonist. Experimental results shown that cholinergic system interact with tetrahydrobiopterin metabolism to decrease pain sensation. This results suggested that an increase in GCH1 regulatory protein(GFRP) expression is involved in analgesic effect by GCH1 inhibitor.
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