Functional analysis of Talin1 in prostate cancer and application into taylormade medicine

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791469
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Chiba University
• Principal Investigator: SAKAMOTO Shinichi 千葉大学, 大学院・医学研究院, 助教 (70422235)
• Project Period (FY): 2010 – 2011
• Keywords: 前立腺癌 / マーカー / 免疫染色 / テーラーメード医療

Research Abstract

Expression of Talin1was significantly up-regulated in prostate cancer compare to benign lesion. Talin1 expression partially correlated with Gleason Score and up-regulated in invasive prostate cancer(pT3) compare to organ confined prostate cancer(pT2). Concerning pre-treatment nomogram, high Talin1 expression may predict invasive prostate cancer among pre-treatment cT1c cases.

Research Products

• [Journal Article] Current Organ Topics (2012)
  • Author(s): 坂本信一, 市川智彦
  • Journal Title: 泌尿器系腫瘍 II 前立腺癌癌と化学療法 Volume: Vol.39巻-1号 Pages: 43-47
  • URL: http://www.pieronline.jp/content/article/0385-0684/39010/43 ; jsessionid=1kh30otgtv7kj.z-sunmedia-live-01
• [Journal Article] 前立腺癌の遺伝子解析概論 (2011)
  • Author(s): 坂本信一, 市川智彦
  • Journal Title: 日本臨床前立腺癌(第2版)-基礎・臨床研究のアップデート- Volume: 増刊号 Pages: 71-75
  • URL: http://www.nippon-rinsho.co.jp/backnum/z_mokuji/6906zenritu.html
• [Journal Article] Talin1 is a Novel Metastasis Promoter via Focal Adhesion Signaling and Anoikis Resistance (2010)
  • Author(s): Sakamoto S, McCann RO, Dhir R, Kyprianou N
  • Journal Title: Cancer Research Volume: Vol. 70 Pages: 1885-95
  • Peer Reviewed
• [Journal Article] Targeting anoikis resistance in prostate cancer metastasis (2010)
  • Author(s): Sakamoto S, Kyprianou N.
  • Journal Title: Journal of molecular aspect of medicine Volume: Vol. 31 Pages: 205-14
  • URL: http://dx.doi.org/10.1016/j.mam.2010.02.001
  • Peer Reviewed
• [Presentation] 前立腺癌新規マーカー解析 (2011)
  • Author(s): 坂本信一
  • Organizer: 第7回千葉泌尿器疾患カンファレンス
  • Place of Presentation: 千葉
  • Year and Date: 2011-09-01
• [Presentation] 前立腺癌におけるTalin1の臨床解析及びノモグラムを活用したテーラーメード医療への応用 (2011)
  • Author(s): 坂本信一
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-04-24
• [Presentation] 基礎部門セッション3『浸潤・転移』 (2010)
  • Author(s): 坂本信一
  • Organizer: 第26回前立腺シンポジウム
  • Place of Presentation: 品川
  • Year and Date: 2010-12-11
• [Book] 第3版前立腺癌のすべて-基礎から最新治療まで-前立腺癌の転移に関する遺伝子 (2012)
  • Author(s): 坂本信一, 他
  • Total Pages: 6
  • Publisher: メディカルビュー社