2011 Fiscal Year Final Research Report
Can GABA agonist improve nocturia symptoms?-basic research to elucidate the relationship between sleep and bladder function
| Project/Area Number |
22791470
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | メラトニン / ゾルピデム / 脳波 / 膀胱 / 睡眠 |
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| Research Abstract |
Intravenous melatonin administration was found to significantly increase intercontraction interval in 24-month-old rats, however, it did not affect micturition voiding pressure, basal pressure, pressure threshold. It showed no significant changes in 10-week-old rats. Electroencephalographic findings showed that melatonin did not influence relative power values in either group. Melatonin increased bladder capacity without affecting bladder pressure in 24-month-old rats and can therefore be expected to be beneficial for treating nocturia in the elderly.
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