2011 Fiscal Year Final Research Report
Development of novel molecular target therapy using high expression protein in prostate cancer
| Project/Area Number |
22791501
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
KAMATA Yuko 東京慈恵会医科大学, 医学部, 助教 (60433984)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 腫瘍学 / 分子標的薬 / ペプチドワクチン |
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| Research Abstract |
To development novel molecular target therapy for prostate cancer, we evaluated prostate cancer specificity and tumor growth suppression effect of three candidate protein, which expressed higher in prostate cancer compared with adjacent non-cancerous area. It was suggest that Minichromosome maintenance complex component 5 was the most promising target. Moreover, another novel candidate of peptide vaccine was identified with analysis of mass spectrometry in prostate cancer cell lines. They might be a novel molecular target of prostate cancer.
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