2011 Fiscal Year Final Research Report
The analysis of molecular mechanism of the precipitation/inhibition of uterine endometrial epithelial cell proliferation by SERM
| Project/Area Number |
22791513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | SERM / 子宮内膜上皮 / 増殖効果 |
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| Research Abstract |
Clomiphene citrate (CC), which has been used for anovulatory infertile women, is thought to be a selective estrogen receptor modulator (SERM). Although CC will restore ovulation in about 80% of anovulatory women, it will result in pregnancy in only about 20~30%. This discrepancy between ovulation and pregnancy success rates may be explained by the peripheral anti-estrogenic effects of CC at the level of the endometrium. However, the molecular mechanisms how CC acts to inhibit the endometrial cell proliferation are still remains to be elusive. We investigated the molecular mechanisms by which CC inhibits the estrogen (E2)-induced endometrial epithelial cell proliferation and CC may inhibit the E2-induced endometrial epithelial cell proliferation and ERα transactivation through inhibiting the recruitment of SRC-1 to ERα.
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