2012 Fiscal Year Final Research Report
Study of regulation of maternal T cell function[s] by placenta specific microRNAs
| Project/Area Number |
22791554
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
ARI Mohamedo 日本医科大学, 医学部, 助教 (50573226)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 産科学 / 妊娠 / マイクロ RNA / 免疫細胞 |
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| Research Abstract |
We hypothesized that circulating placenta-specific miRNAs could be delivered to maternal lymphocytes via exosomes and could be functional in the recipient cells. We tested this hypothesis using an in vitro model system; the human trophoblast cell line BeWo and T cell lymphoblast-like cell line Jurkat. We demonstrated the miRNAs present in BeWo-exosomes to be capable of modulating gene expression in Jurkat cells using in the in vitro model system. We provide a new insight into cell-cell communication via exosomes between placenta and lymphocytes.
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[Journal Article] Hydroxysteroid (17-β) dehydrogenase1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas:a novel marker for predicting preeclampsia.2012
Author(s)
Ishibashi O, Ohkuchi A, Ali MM , Kurashina R, Luo SS, Ishikawa T, Takizawa T, Hirashima C, Takahashi K , Migita M, Ishikawa G, Yoneyama K, Asakura H, Izumi A, Matsubara S, Takeshita T, Takizawa T.
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Journal Title
Hypertension
Volume: 59
Pages: 265-273
DOI
Peer Reviewed
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[Presentation] 胎盤由来エクソソームを介した胎盤-母体間コミュニケーション2011
Author(s)
菊池邦生,アリモハメド,羅善順,石橋宰,石川朋子,瀧澤敬美,倉品隆平,石川源,右田真,大口昭英,松原茂樹,竹下俊行,瀧澤俊広
Organizer
第19回日本胎盤学会学術集会/第29回日本絨毛性疾患研究会
Place of Presentation
東京
Year and Date
2011-10-01
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[Presentation] 胎盤由来のエクソソーム:胎盤特異的microRNAはエクソソームを介して母体循環に分泌される2011
Author(s)
瀧澤俊広,アリハメド,羅善順,石橋宰,菊池邦生,石川朋子,瀧澤敬美,倉品隆平,右田真,大口昭英,松原茂樹,竹下俊行
Organizer
第84回日本生化学会大会
Place of Presentation
京都
Year and Date
2011-09-22
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