The functional analysis of a transcriptional factor GATA3 in an inner ear development.

2011 Fiscal Year Final Research Report

• Project/Area Number: 22791567
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: University of Tsukuba
• Principal Investigator: HOSHINO Tomofumi 筑波大学, 医学医療系, 講師 (00550534)
• Research Collaborator: HAYASHI Kentaro 筑波大学, 人間総合科学研究科, 研究生 ; TABUCHI Keiji 筑波大学, 医学医療系, 講師 ; HARA Akira 筑波大学, 医学医療系, 教授 ; YAMAMOTO Masayuki 東北大学, 大学院・医学系研究科, 教授
• Project Period (FY): 2010 – 2011
• Keywords: 転写因子 / GATA3 / 内耳 / 発生

Research Abstract

Because the transcriptional factor GATA3 express in otic vesicles and inner ears, it is suggested that GATA3 is important for the developmental pathway of the inner ear. Little is known about the function of GATA3 in developmental pathway because of lethality of Gata3 knockout mouse. Then, we used the new approach, a transgenic rescue technique. This clarified that part of Gata3-null-ears occurs to inner ear malformation. This result indicates GATA3 is indispensable to form the inner ear from the otic vesicle.

Research Products

• [Journal Article] Protectiverole of Nrf2 in age-related hearingloss and gentamicin ototoxicity (2011)
  • Author(s): Hoshino T, Tabuchi K, Nishimura B, Tanaka S, Nakayama M, Ishii T, Warabi E, Yanagawa T, Shimizu R, Yamamoto M, Hara A
  • Journal Title: Biochem. Biophys. Res. Commum Volume: Vol.415 Pages: 94-98
  • Peer Reviewed
• [Journal Article] Age-related hearing loss and expression of antioxidant enzymes in BDF1 mice (2011)
  • Author(s): Tabuchi K, Hoshino T, Hirose Y, Hayashi K, Nishimura B, Nakayama M, Hara A
  • Journal Title: Acta. Otolaryngol Volume: Vol.131 Pages: 1020-1024
  • Peer Reviewed
• [Journal Article] c-Ret-mediated hearing loss in mice with Hirschsprung disease (2010)
  • Author(s): Ohgami N, Ida-Eto M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A Volume: Vol.107 Pages: 13051-13056
  • Peer Reviewed
• [Journal Article] Effects of NSAIDs on the Inner Ear : Possible Involvement in Cochlear Protection (2010)
  • Author(s): Hoshino T, Tabuchi K, Hara A
  • Journal Title: Pharmaceuticals Volume: Vol.3 Pages: 1286-1295
  • Peer Reviewed
• [Journal Article] Protective effects of exogenous GM-1 ganglioside on acoustic injury of the mouse cochlea (2010)
  • Author(s): Tanaka S, Tabuchi K, Hoshino T, Murashita H, Tsuji S, Hara A
  • Journal Title: Neurosci. Lett Volume: Vol.473 Pages: 237-241
  • Peer Reviewed
• [Presentation] 聴力改善手術における術前検査の有用性 (2011)
  • Author(s): 星野朝文, 原晃
  • Organizer: 日本耳科学会学術講演会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2011-11-24
• [Presentation] 内視鏡下経鼻下垂体手術後の鼻腔形態について (2011)
  • Author(s): 星野朝文, 原晃, 阿久津博義, 高野晋吾, 村下秀和
  • Organizer: 日本耳鼻咽喉科学会学術講演会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-05-19
• [Presentation] Expression of Antioxidant Enzymes in Aged Mice (2010)
  • Author(s): Hoshino T, Tabuchi K, Hara A
  • Organizer: Sixth international symposium on Meniere's disease and inner ear disorders
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2010-11-14