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2011 Fiscal Year Final Research Report

Roles and modes of nectins in the development and regeneration of the olfactory epithelium

Research Project

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Project/Area Number 22791599
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKobe University

Principal Investigator

KATSUNUMA Sayaka  神戸大学, 医学部附属病院, 助教 (80457043)

Project Period (FY) 2010 – 2011
Keywords嗅上皮
Research Abstract

The olfactory epithelium, which is located inside the nasal cavity, is a specialized sensory epithelium. In this study, we observed the cellular arrangements of supporting cells and olfactory cells in the developing mouse olfactory epithelium. We found that nectins were distributed in differential and complementary patterns in the apical cell-cell contact sites of the olfactory epithelium. We investigated the effect of a mixed culture experiment of the cells expressing differential adhesion molecules. Various cellular arrangements were formed depending on the adhesion molecules. Thus, we revealed that interactions of nectins are implicated in these cellular rearrangements in the olfactory epithlium.

  • Research Products

    (4 results)

All 2011 2010

All Journal Article (2 results) Presentation (2 results)

  • [Journal Article] Vestibular dysfunction and compensation after removal of acoustic neuroma2011

    • Author(s)
      Natsumi Uehara, Hitoshi Tanimoto, Tasuku Nishikawa, Kiyoshi Doi, Sayaka Katsunuma, Hidehito Kimura, Eiji Kohmura, Ken-ichi Nibu
    • Journal Title

      Journal and Vestibular Research

      Volume: 21(5) Pages: 289-95

  • [Journal Article] Bone marrow stem cell transplantation to olfactory epithelium2010

    • Author(s)
      Ochi N, Doi K, Uranagase M, Nishikawa T, Katsunuma S, Nibu K.
    • Journal Title

      Ann Otol Rhinol Laryngol

      Volume: 119(8) Pages: 535-40

  • [Presentation] Roles and modes of action of nectins and cadherins in the morphogenesis of the olfactory epithelium2011

    • Author(s)
      Sayaka Katsunuma
    • Organizer
      11th Japan-Taiwan Conference on Otolary ngology-Head and Neck Surgery
    • Place of Presentation
      神戸(日本)
    • Year and Date
      2011-11-09
  • [Presentation] 嗅上皮の形態形成と再生における細胞接着分子の機能2010

    • Author(s)
      勝沼紗矢香
    • Organizer
      日本鼻科学会
    • Place of Presentation
      仙台(日本)
    • Year and Date
      2010-08-25

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Published: 2013-07-31  

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