2012 Fiscal Year Final Research Report
Development of macrophage migration inhibitory factor DNA vaccine against inflammatory ocular disease
| Project/Area Number |
22791645
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KITAMEI Hirokuni 北海道大学, 大学院・医学研究科, 客員研究員 (90451426)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ぶどう膜炎 / MIF / ワクチン |
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| Research Abstract |
We made an effort to develop the vaccine against serious endogenous uveitis. First, mice received a DNA vaccine against proinflammatory cytokine, macrophagemigration inhibitory factor (MIF), and then the mice were immunized to induceexperimental autoimmune uveoretinitis (EAU), an animal model for humanendogenous uveitis. The severity of EAU was successfully milder after vaccinationthan controls. However, antibody levels were not elevated enough in some subjects.
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