2011 Fiscal Year Final Research Report
To investigate molecular mechanisms for dynamics of retinal angiogenesis using time-lapse imaging
| Project/Area Number |
22791654
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 眼生化学 / 分子生物学 |
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| Research Abstract |
We established a novel time-lapse imaging for retinal angiogenesis in retinal explants. The quantification elucidated both dynamic and static phases in angiogenic sprouting. Further, we demonstrated a novel finding that SDF-1 and GSK-3βregulate the motility of vascular endothelial cells in retinal angiogenesis.
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