2011 Fiscal Year Final Research Report
functional analyses of Angptl2 in pathogenesis of diabetic retinopathy
| Project/Area Number |
22791671
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
ITO Yasuhiro 熊本大学, 医学部附属病院, 助教 (70380996)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 眼生化学 / 分子生物学 |
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| Research Abstract |
Concentration of Angptl2 in vitreous of patients with proliferative diabetic retinopathy was increased compared to the control, and Angptl2 expression was found in fibrovascular membrane of proliferative diabetic retinopathy. Moreover, IL-6, MCP-1, ICAM-1 and VCAM-1 expression was decreased in Angptl2 knockout mice compared to the control, and leukocyte adhesion to endothelial cells was suppressed in Angptl2 knockout mice.
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