2011 Fiscal Year Final Research Report
Effect of lipopolysaccaride and hyperglycemia on monocytic cell phagocytosis and cell death and its associated intracellurar pathway.
| Project/Area Number |
22791752
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 敗血症 / 高血糖 / 単球系細胞 / 炎症消退脂質 |
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| Research Abstract |
To make a in vitro model of septic condition, monocytic cells were exposed with lipopolysaccaride and hyperglycemia, which induced apoptosis, inhibited secretion of proinflammatory cytokine, and phagocytosis. Our results suggest that ER stress and Akt phosphorylation are primary involved as the upstream modulator. Furthermore, Resolvin D2, known as a lipid mediator in resolution of inflammation, suppressed apoptosis and improved phagocytosis, which results indicate that Resolvin D2 have the potential lipid mediator for treating sepsis.
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