2012 Fiscal Year Final Research Report
Role of extracellular ATP in the pathogenesis of ventilator-induced lung injury
| Project/Area Number |
22791753
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 人工呼吸関連肺損傷 |
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| Research Abstract |
We investigated the role of extracellular ATP in ventilator-induce lung injury .Extracellular ATP increased with the increase in tidal volume of mechanical ventilation. The increase of ATP in the sepsis model mice tended to be larger than that in the healthy mice, suggesting that ATP had some role in the inflammatory reaction in VALI. It was not fully examined whether the inhibition of ATP could improve the VALI.
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[Journal Article] Satoru HashimotoSuccessful treatment of severe asthma-associated plastic bronchitis with extracorporeal membrane oxygenation.2012
Author(s)
Momoka Tonan, Soshi Hashimoto, AkioKimura, Hiroki Matsuyama, HiromiKinose, Maiko Sawada, Nobuaki Shime, Natsuko Tokuhira, Yuko Kato, Masayuki Sasaki, Kunihiko Tsuchiya, Satoshi Higaki, Tadaki Oomae
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Journal Title
J Anesth
Volume: 26(2)
Pages: 265-8
Peer Reviewed
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