2012 Fiscal Year Final Research Report
Osteocytic regulation on osteoclastic bone resorption and survival/death of osteocytes
| Project/Area Number |
22791760
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
SUZUKI Reiko 北海道大学, 大学院・歯学研究科, 専門研究員 (90333723)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 細胞・組織 / 骨細胞 / 破骨細胞 |
|---|
| Research Abstract |
Osteocytes are shown to synthesize sclerostin and dentin matrix protein-1 (DMP-1), which serve to inhibit osteoblastic activities and subsequent bone remodeling, and regulate surrounding mineralization by binding to calcium ion of calcium phosphate crystals in bone, respectively. In a state of accelerated bone resorption, osteocytes decreased sclerostin synthesis in accordance with stimulated osteoclastic activities. The decreased synthesis of sclerostin appears to be not interrupt accelerated osteoclastic bone resorption by mediating osteoblasts.
|
-
[Journal Article] Morphological aspects of the biological function of the osteocytic lacunar canalicular system and of osteocyte-derived factors.2012
Author(s)
Sasaki M., Hongo H., Hasegawa T., Suzuki R., Liu Z., Freitas PHL., Yamada T., Oda K., Yamamoto T., Li M., Totsuka Y., Amizuka N.
-
Journal Title
Oral Science International.
Volume: 9(1)
Pages: 1-8
URL
Peer Reviewed
-
-
[Journal Article] Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats.2012
Author(s)
Guo Y., Li M., Liu Z., Sasaki M., Hasegawa T., Hongo H., Tabata C., Suzuki R., Oda K., Yamamoto T., Kawanami M., Amizuka N.
-
Journal Title
J Electron Microsc.
Volume: 61(5)
Pages: 309-320
DOI
Peer Reviewed
-
[Journal Article] The distribution of osteocytic lacunar-canalicular system, and immunolocalization of FGF23 and sclerostin in osteocytes.2012
Author(s)
Amizuka N., Hongo H., Sasaki M., Hasegawa T., Suzuki R., Tabata C., Ubaidus S., Masuki H., Guo Y., Freitas PHL., Oda K., Li M.
-
Journal Title
J Oral Biosci.
Volume: 54(1)
Pages: 37-42
URL
Peer Reviewed
-
[Journal Article] Morphological assessment of bone mineralization in tibial metaphyses of ascorbic acid-deficient ODS rats.2011
Author(s)
Hasegawa T., Li M., Hara K., Sasaki M., Tabata C., Freitas PHL., Hongo H., Suzuki R., Kobayashi M., Inoue K., Yamamoto T., Oohata N., Oda K., Akiyama Y., Amizuka N.
-
Journal Title
Biomed Res.
Volume: 32(4)
Pages: 259-269
URL
Peer Reviewed
-
[Journal Article] Ultrastructural observation on cells meeting the histological criteria for preosteoblasts - a study in the mouse tibial metaphysis.2010
Author(s)
Narimatsu K., Li M., Freitas PHL., Sultana S., Ubaidus S., Kojima T., Liu Z., Guo Y., Suzuki R., Yamamoto T., Oda K., Amizuka N.
-
Journal Title
J Electron Microsc.
Volume: 59(5)
Pages: 427-436
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
