2012 Fiscal Year Final Research Report
Functional analyses on DKK gene family in head and neck squamous cell carcinoma
| Project/Area Number |
22791766
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KATASE Naoki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30566071)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 頭頸部扁平上皮癌 / DKK3 / 癌抑制遺伝子 / 機能解析 / siRNA / 生存分析 |
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| Research Abstract |
In this research project, functions of DKK3 gene were investigated in head and neck squamous cell carcinoma (HNSCC). Although DKK3 is reported to function as tumor suppressor in kinds of tumors, the present researches demonstrated contradict findings. In HNSCC, DKK3 mRNA and protein were dominantly expressed, unlike those in other cancers were attenuated or lost because of promoter methylation. Survival analyses revealed that DKK3 protein(-) patients showed longer survival. Knockdown of DKK3 mRNA by siRNA in HNSCC cell lines resulted in decreased cellular migration and invasion. All the data strongly imply the paradoxical function of DKK3 in HNSCC.
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