2011 Fiscal Year Final Research Report
Tooth morphogenesis and the regulation of phosphate homeostasis : basic and preclinical studies of tooth hypoplasia
| Project/Area Number |
22791768
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
YOSHIOKA Hirotaka 広島大学, 大学院・医歯薬学総合研究科, 助教 (50523411)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | リン酸代謝 / 歯牙形成 / 石灰化 / エナメル質 |
|---|
| Research Abstract |
Microarray analysis identified the odontogenesis-related genes influenced by inorganic phosphate(Pi) overload. Among the genes identified by microarray analysis, fibromodulin was downregulated in an extracellular Pi level-dependent manner in both cultured tooth germs and differentiated ameloblast lineage cells. This suppression of fibromodulin gene was dependent on ERK1/ 2-Egr1 signaling pathway in differentiated ameloblast lineage cells. These data suggest that the fibromodulin may be involved in the etiology of enamel hypoplasia caused by hyperphosphatemia.
|
-
-
-
-
-
-
[Presentation] Shimizu A, AubinJ, Maeda N. MEPE-Derived Phosphorylated ASARM Is Involved inFGF23/ soluble Klotho-DependentHypomineralization2011
Author(s)
Konishi Y, Yoshiko Y, Minamizaki T, Yoshioka H, Maeda M, Shimizu A, AubinJ, Maeda N
Organizer
The 33rd AnnualMeeting of the American Society forBone and Mineral Research
Place of Presentation
San Diego, CA, USA
Year and Date
20110900
-
-
-
-
-
-
-
-
-
