2013 Fiscal Year Final Research Report
The role os IL-18 and Th17 cells in the T cell related immune system of Sjogren's syndrome
| Project/Area Number |
22791806
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
SAKAI AZUSA 東北大学, 大学病院, 医員 (90463778)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | シェーグレン症候群 / 唾液腺 |
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| Research Abstract |
The purpose of this research was to investigate the pathogenesis of Sjogren's syndrome. The expression of IL-18 and IL-17 were detected in salivary glands of Sjogren's syndrome, and infiltrating T cells. IL-18 amplified the secretion of IL-8 and IL-6 induced by low amounts of IL-17 from primary salivary glands cells. The results suggest that IL-18 and Th17 cells are associated with the pathogenesis of Sjogren's syndrome.
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