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2011 Fiscal Year Final Research Report

Regulation of Serotonin receptor gene expression by brain-specific non-coding RNAs.

Research Project

  • PDF
Project/Area Number 22791817
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionThe Nippon Dental University

Principal Investigator

SOENO Yuuichi  日本歯科大学, 生命歯学部, 講師 (70350139)

Project Period (FY) 2010 – 2011
Keywords病態病理学
Research Abstract

While snoRNAs generally mediate the maturation of rRNAs, brain-specific MBII-52 snoRNA has a complementarity to serotonin receptor 2C mRNA. To investigate the not-yet-known function of MBII-52 we analyzed the transcripts and the MBII-52/protein complex in mouse brain. Our results demonstrated that MBII-52 form novel complexes with Nucleolin and ELAVL1, and that some MBII-52 variants are processed into a shorter form according to the nucleotide polymorphism.

  • Research Products

    (5 results)

All 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] ノンコーディングRNAによる遺伝子発現制御と病態-セロトニン受容体修飾と摂食障害2011

    • Author(s)
      添野雄一, 藤田和也, 田谷雄二, 青葉孝昭
    • Journal Title

      歯学

      Volume: 98 Pages: 185-188

  • [Journal Article] Identification of novel ribonucleo-protein complexes from the brain-specific snoRNA MBII-522010

    • Author(s)
      Soeno, Y., Taya, Y., Stasyk, T., Huber, L. A., Aoba, T., Huttenhofer A.
    • Journal Title

      RNA

      Volume: 16 Pages: 1293-1300

    • Peer Reviewed
  • [Presentation] マウス染色体7C snoRNAクラスター領域からのMBII-52バリアント発現プロファイル2010

    • Author(s)
      添野雄一、田谷雄二、藤田和也、Alexander Huttenhoffer、青葉孝昭
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      兵庫県、合同大会プログラム
    • Year and Date
      2010-12-08
  • [Presentation] A Mouse Model Lacking U50 box C/D-type snoRNA Expression2010

    • Author(s)
      Soeno, Y., Fujita, K., Kudo, T., Taya, Y., and Aoba, T.
    • Organizer
      The 15th Annual Meeting of the RNA society
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2010-06-24
  • [Remarks]

    • URL

      http://www.ndu.ac.jp/~pathhome/index/

URL: 

Published: 2013-07-31  

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