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2012 Fiscal Year Final Research Report

The new painless local application of antibiotics by use of iontophoresis with alternative current

Research Project

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Project/Area Number 22791958
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

WAKITA Ryo  東京医科歯科大学, 歯学部附属病院, 助教 (60376712)

Project Period (FY) 2010 – 2012
Keywords歯科麻酔学
Research Abstract

We have investigated the energized condition for the purpose of antimicrobial drug administration to the intradermal tissue for a long time using an AC iontophoresis. These results indicated that a variable electric field with a DC component were ideal for waveform to be applied and 1% or less concentration of alginate were suitable as the drug retention material. But we also revealed there are advantages in a sine wave and a square wave, respectively. Therefore it is necessary to examine more optimal conditions of iontophoresis using alternating current.

  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (2 results) Presentation (3 results)

  • [Journal Article] In vitro evaluation of calcium alginate gels as matrix for iontophoresis electrodes2012

    • Author(s)
      Haida H, Ando S, Ogami S, Wakita R, Kohase H, Saito N, Yoshioka T, Ikoma T, Tanaka J, Umino M, and Fukayama H
    • Journal Title

      Journal of Medical and Dental Sciences

      Volume: 59(1) Pages: 9-16

  • [Journal Article] The relation between the duty cycle and anesthetic effect in lidocaine iontophoresis using alternating current2011

    • Author(s)
      Wakita R, Nakajima A, Haida Y, Umino M, Fukayama H
    • Journal Title

      Pain Practice

      Volume: 11(3) Pages: 261-6

  • [Presentation] THE EFFICACY OF IONTOPHORESIS USING THE BIPOLAR SQUARE WAVE WITH DUTYCYCLE2011

    • Author(s)
      R. Wakita, A. Nakajima, H. Haida, H. Fukayama
    • Organizer
      the 30th Annual ESRA Congress
    • Place of Presentation
      Germany
    • Year and Date
      2011-09-08
  • [Presentation] 交流イオントフォレーシスを用いたリドカイン送達における波形の影響2010

    • Author(s)
      中島淳,脇田亮,灰田悠,安藤寧,深山治久
    • Organizer
      第38回日本歯科麻酔学会総会
    • Place of Presentation
      神奈川
    • Year and Date
      2010-10-08
  • [Presentation] Electrochemical Deposition of Alginic Acid on Metal Surfaces for theDevelopment of Iontophoresis Electrode2010

    • Author(s)
      N. Saito, T. Yoshioka, T. Ikoma, N.Ohashi, H. Haida, S. Ogami, R. Wakita, H. Kohase, M.Umino and J. Tanaka
    • Organizer
      Fourth international conference on the science and technology for advanced ceramics (STAC-4)
    • Place of Presentation
      神奈川
    • Year and Date
      2010-06-21

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Published: 2014-08-29  

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