2011 Fiscal Year Final Research Report
Bone tissue engineering by human dental pulp cells
| Project/Area Number |
22791960
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HAMADA Keiichi 東京医科歯科大学, 歯学部, 非常勤講師 (60570025)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 骨 / 再生医療 / 歯髄 / 無血清培地 |
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| Research Abstract |
The aim of this study is to develop a new way of bone tissue engineering by human dental pulp cells cultured without serum and osteogenic differentiation induction. Human dental pulp cells could be cultured and expanded in serum-free medium. There were no differences in alkaline phosphatase activity and expression of osteocalin between human dental pulp cell expanded in serum-free medium and in medium containing fetal bovine serum. Human dental pulp cells expanded in serum free medium formed mineralized tissues in vivo, but it is not typical bone tissues.
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