2011 Fiscal Year Final Research Report
Hyperthermia using magnetic nanoparticles combined with intratumoral dendritic cells enhance antitumor effect for oral cancer metastasis model
| Project/Area Number |
22791971
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 温熱療法 / 免疫療法 / 口腔癌 / 扁平上皮癌 / 磁性微粒子 / 樹上細胞 / マイルド加温 |
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| Research Abstract |
The aims of this study were to explore the feasibility of a novel combination therapy comprising hyperthermia(HT) and dendritic cell(DC) application for oral squamous cell carcinoma(OSCC) metastasis model, and to optimize the conditions of this therapy. A more suppressive effect of tumor growth was observed, and cytotoxic T cell infiltration was significantly increased by adding mHT compared to conventional only simple HT with DCs. These phenomena also occurred in non-treated contralateral tumors as well as treated ones. Our data suggest that the combination of 43℃preheated simple HT SCCVII tumors and additional 41℃heat mHT promotes DC maturation, resulting in suppression of tumor growth systemically and lifetime prolongation in mice. A three-step process of additional mHT after local HT and intratumoral immature DC(iDC) injection could be a more effective and novel method for the treatment of OSCC.
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