2011 Fiscal Year Final Research Report
Study of molecular mechanisms of salivary gland development by Snail family genes.
| Project/Area Number |
22791973
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 唾液腺発達 / Snail |
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| Research Abstract |
Snail family genes, snail and slug, which were identified as a epithelial mesenchymal transition, were expressed in epithelial cells of developing salivary glands. We examined the effect of gene-knock down and over-expression of snail family genes on development of salivary gland in explant culture. We found that branching development was inhibited by Snail/ Slug siRNA treatment and stimulated by Snail/ Slug over-expression. These data suggested that Snail and Slug plays stimulatory roles in branching development of salivary gland.
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