2011 Fiscal Year Final Research Report
The mechanism of the myofunctional recovery using RNA interference aiming at the treatment of the skeletal muscle disorder
| Project/Area Number |
22792055
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KAWAI Nobuhiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40437588)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 筋ジストロフィー / マイオスタチン / RNA干渉 / 筋電図 / 咀嚼筋 |
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| Research Abstract |
The purpose of this study was to evaluate the efficiency of a myostatin-targeting siRNA(Mst-siRNA) for the recovery of muscle functions using muscular dystrophy model mice. The injection of the Mst-siRNA into the masseter muscle induced an increase in muscle mass and a muscle activity. These results suggested that the administration of Mst-siRNA might be a candidate for the treatment of muscular atrophy.
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